Fengycin A Analogues with Enhanced Chemical Stability and Antifungal Properties

[Image: see text] Fengycins are cyclic lipo-depsipeptides produced by Bacillus spp. that display potent antifungal properties but are chemically unstable. This instability has meant that no total synthesis of any fengycin has been published. Here we report the synthesis of fengycin A analogues that...

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Autores principales: Gimenez, Diana, Phelan, Aoife, Murphy, Cormac D., Cobb, Steven L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289291/
https://www.ncbi.nlm.nih.gov/pubmed/34077216
http://dx.doi.org/10.1021/acs.orglett.1c01387
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author Gimenez, Diana
Phelan, Aoife
Murphy, Cormac D.
Cobb, Steven L.
author_facet Gimenez, Diana
Phelan, Aoife
Murphy, Cormac D.
Cobb, Steven L.
author_sort Gimenez, Diana
collection PubMed
description [Image: see text] Fengycins are cyclic lipo-depsipeptides produced by Bacillus spp. that display potent antifungal properties but are chemically unstable. This instability has meant that no total synthesis of any fengycin has been published. Here we report the synthesis of fengycin A analogues that display enhanced antifungal properties and chemical stability under both basic and acidic conditions. The analogues prepared also demonstrate that the fengycin core structure can be modified and simplified without the loss of antifungal activity.
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spelling pubmed-82892912021-07-20 Fengycin A Analogues with Enhanced Chemical Stability and Antifungal Properties Gimenez, Diana Phelan, Aoife Murphy, Cormac D. Cobb, Steven L. Org Lett [Image: see text] Fengycins are cyclic lipo-depsipeptides produced by Bacillus spp. that display potent antifungal properties but are chemically unstable. This instability has meant that no total synthesis of any fengycin has been published. Here we report the synthesis of fengycin A analogues that display enhanced antifungal properties and chemical stability under both basic and acidic conditions. The analogues prepared also demonstrate that the fengycin core structure can be modified and simplified without the loss of antifungal activity. American Chemical Society 2021-06-02 2021-06-18 /pmc/articles/PMC8289291/ /pubmed/34077216 http://dx.doi.org/10.1021/acs.orglett.1c01387 Text en © 2021 The Authors. Published by American Chemical Society Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Gimenez, Diana
Phelan, Aoife
Murphy, Cormac D.
Cobb, Steven L.
Fengycin A Analogues with Enhanced Chemical Stability and Antifungal Properties
title Fengycin A Analogues with Enhanced Chemical Stability and Antifungal Properties
title_full Fengycin A Analogues with Enhanced Chemical Stability and Antifungal Properties
title_fullStr Fengycin A Analogues with Enhanced Chemical Stability and Antifungal Properties
title_full_unstemmed Fengycin A Analogues with Enhanced Chemical Stability and Antifungal Properties
title_short Fengycin A Analogues with Enhanced Chemical Stability and Antifungal Properties
title_sort fengycin a analogues with enhanced chemical stability and antifungal properties
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289291/
https://www.ncbi.nlm.nih.gov/pubmed/34077216
http://dx.doi.org/10.1021/acs.orglett.1c01387
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