The Emerging Clinical Application of m6A RNA Modification in Inflammatory Bowel Disease and Its Associated Colorectal Cancer

Methylation, first proposed in DNAs, but later found in RNAs, serves as one of the most widespread epigenetic modifications in eukaryotes, where N6-methyladenosine (m6A) modification has been found to play an important role in a variety of cancers including colorectal cancer (CRC). Under the action...

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Autores principales: Xu, Xinwei, Huang, Jintu, Ocansey, Dickson Kofi Wiredu, Xia, Yuxuan, Zhao, Zihan, Xu, Zhiwei, Yan, Yongmin, Zhang, Xu, Mao, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289367/
https://www.ncbi.nlm.nih.gov/pubmed/34290515
http://dx.doi.org/10.2147/JIR.S320449
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author Xu, Xinwei
Huang, Jintu
Ocansey, Dickson Kofi Wiredu
Xia, Yuxuan
Zhao, Zihan
Xu, Zhiwei
Yan, Yongmin
Zhang, Xu
Mao, Fei
author_facet Xu, Xinwei
Huang, Jintu
Ocansey, Dickson Kofi Wiredu
Xia, Yuxuan
Zhao, Zihan
Xu, Zhiwei
Yan, Yongmin
Zhang, Xu
Mao, Fei
author_sort Xu, Xinwei
collection PubMed
description Methylation, first proposed in DNAs, but later found in RNAs, serves as one of the most widespread epigenetic modifications in eukaryotes, where N6-methyladenosine (m6A) modification has been found to play an important role in a variety of cancers including colorectal cancer (CRC). Under the action of various enzymes and proteins, the regulatory role of m6A in RNAs and immune cells has also been gradually realized. This paper reviews the general biogenesis and effects of m6A, and its emerging crucial role in intestinal mucosal immunity via the regulation of RNAs and immune cells, and thus closely related to the occurrence and development of inflammatory bowel disease (IBD) and CRC. m6A-related genes and regulatory factors are expected to be potential predictive markers and therapeutic targets.
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spelling pubmed-82893672021-07-20 The Emerging Clinical Application of m6A RNA Modification in Inflammatory Bowel Disease and Its Associated Colorectal Cancer Xu, Xinwei Huang, Jintu Ocansey, Dickson Kofi Wiredu Xia, Yuxuan Zhao, Zihan Xu, Zhiwei Yan, Yongmin Zhang, Xu Mao, Fei J Inflamm Res Review Methylation, first proposed in DNAs, but later found in RNAs, serves as one of the most widespread epigenetic modifications in eukaryotes, where N6-methyladenosine (m6A) modification has been found to play an important role in a variety of cancers including colorectal cancer (CRC). Under the action of various enzymes and proteins, the regulatory role of m6A in RNAs and immune cells has also been gradually realized. This paper reviews the general biogenesis and effects of m6A, and its emerging crucial role in intestinal mucosal immunity via the regulation of RNAs and immune cells, and thus closely related to the occurrence and development of inflammatory bowel disease (IBD) and CRC. m6A-related genes and regulatory factors are expected to be potential predictive markers and therapeutic targets. Dove 2021-07-15 /pmc/articles/PMC8289367/ /pubmed/34290515 http://dx.doi.org/10.2147/JIR.S320449 Text en © 2021 Xu et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Xu, Xinwei
Huang, Jintu
Ocansey, Dickson Kofi Wiredu
Xia, Yuxuan
Zhao, Zihan
Xu, Zhiwei
Yan, Yongmin
Zhang, Xu
Mao, Fei
The Emerging Clinical Application of m6A RNA Modification in Inflammatory Bowel Disease and Its Associated Colorectal Cancer
title The Emerging Clinical Application of m6A RNA Modification in Inflammatory Bowel Disease and Its Associated Colorectal Cancer
title_full The Emerging Clinical Application of m6A RNA Modification in Inflammatory Bowel Disease and Its Associated Colorectal Cancer
title_fullStr The Emerging Clinical Application of m6A RNA Modification in Inflammatory Bowel Disease and Its Associated Colorectal Cancer
title_full_unstemmed The Emerging Clinical Application of m6A RNA Modification in Inflammatory Bowel Disease and Its Associated Colorectal Cancer
title_short The Emerging Clinical Application of m6A RNA Modification in Inflammatory Bowel Disease and Its Associated Colorectal Cancer
title_sort emerging clinical application of m6a rna modification in inflammatory bowel disease and its associated colorectal cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289367/
https://www.ncbi.nlm.nih.gov/pubmed/34290515
http://dx.doi.org/10.2147/JIR.S320449
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