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Frank’s Sign in Polycystic Ovary Syndrome and Sideburn Adiposity: A Case Report and Illustrated Hypothesis
The diagnosis of polycystic ovary syndrome (PCOS) remains uniquely dependent on physical examination signs. Diagonal earlobe crease (DELC) also referred to as “Frank’s sign, has been associated with several cardiometabolic disorders with further investigations reporting that its occurrence was more...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Cureus
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289398/ https://www.ncbi.nlm.nih.gov/pubmed/34290927 http://dx.doi.org/10.7759/cureus.15744 |
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author | Abrahim, Mohammed |
author_facet | Abrahim, Mohammed |
author_sort | Abrahim, Mohammed |
collection | PubMed |
description | The diagnosis of polycystic ovary syndrome (PCOS) remains uniquely dependent on physical examination signs. Diagonal earlobe crease (DELC) also referred to as “Frank’s sign, has been associated with several cardiometabolic disorders with further investigations reporting that its occurrence was more prevalent among aging men and thought to a sign of aging skin. However, there is no clear mechanism of development or rationale behind such associations. The author is reporting a novel association between Frank's sign and PCOS in a 23-year-old female patient. The presence of the DELC in young women could alert clinicians to the need to further investigate a diagnosis of PCOS. The author is providing an accompanying hypothesis to suggest possible common pathogenesis that links the two to visceral adiposity of the face. |
format | Online Article Text |
id | pubmed-8289398 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-82893982021-07-20 Frank’s Sign in Polycystic Ovary Syndrome and Sideburn Adiposity: A Case Report and Illustrated Hypothesis Abrahim, Mohammed Cureus Endocrinology/Diabetes/Metabolism The diagnosis of polycystic ovary syndrome (PCOS) remains uniquely dependent on physical examination signs. Diagonal earlobe crease (DELC) also referred to as “Frank’s sign, has been associated with several cardiometabolic disorders with further investigations reporting that its occurrence was more prevalent among aging men and thought to a sign of aging skin. However, there is no clear mechanism of development or rationale behind such associations. The author is reporting a novel association between Frank's sign and PCOS in a 23-year-old female patient. The presence of the DELC in young women could alert clinicians to the need to further investigate a diagnosis of PCOS. The author is providing an accompanying hypothesis to suggest possible common pathogenesis that links the two to visceral adiposity of the face. Cureus 2021-06-18 /pmc/articles/PMC8289398/ /pubmed/34290927 http://dx.doi.org/10.7759/cureus.15744 Text en Copyright © 2021, Abrahim et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Endocrinology/Diabetes/Metabolism Abrahim, Mohammed Frank’s Sign in Polycystic Ovary Syndrome and Sideburn Adiposity: A Case Report and Illustrated Hypothesis |
title | Frank’s Sign in Polycystic Ovary Syndrome and Sideburn Adiposity: A Case Report and Illustrated Hypothesis |
title_full | Frank’s Sign in Polycystic Ovary Syndrome and Sideburn Adiposity: A Case Report and Illustrated Hypothesis |
title_fullStr | Frank’s Sign in Polycystic Ovary Syndrome and Sideburn Adiposity: A Case Report and Illustrated Hypothesis |
title_full_unstemmed | Frank’s Sign in Polycystic Ovary Syndrome and Sideburn Adiposity: A Case Report and Illustrated Hypothesis |
title_short | Frank’s Sign in Polycystic Ovary Syndrome and Sideburn Adiposity: A Case Report and Illustrated Hypothesis |
title_sort | frank’s sign in polycystic ovary syndrome and sideburn adiposity: a case report and illustrated hypothesis |
topic | Endocrinology/Diabetes/Metabolism |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289398/ https://www.ncbi.nlm.nih.gov/pubmed/34290927 http://dx.doi.org/10.7759/cureus.15744 |
work_keys_str_mv | AT abrahimmohammed frankssigninpolycysticovarysyndromeandsideburnadiposityacasereportandillustratedhypothesis |