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Frank’s Sign in Polycystic Ovary Syndrome and Sideburn Adiposity: A Case Report and Illustrated Hypothesis

The diagnosis of polycystic ovary syndrome (PCOS) remains uniquely dependent on physical examination signs. Diagonal earlobe crease (DELC) also referred to as “Frank’s sign, has been associated with several cardiometabolic disorders with further investigations reporting that its occurrence was more...

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Detalles Bibliográficos
Autor principal: Abrahim, Mohammed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289398/
https://www.ncbi.nlm.nih.gov/pubmed/34290927
http://dx.doi.org/10.7759/cureus.15744
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author Abrahim, Mohammed
author_facet Abrahim, Mohammed
author_sort Abrahim, Mohammed
collection PubMed
description The diagnosis of polycystic ovary syndrome (PCOS) remains uniquely dependent on physical examination signs. Diagonal earlobe crease (DELC) also referred to as “Frank’s sign, has been associated with several cardiometabolic disorders with further investigations reporting that its occurrence was more prevalent among aging men and thought to a sign of aging skin. However, there is no clear mechanism of development or rationale behind such associations. The author is reporting a novel association between Frank's sign and PCOS in a 23-year-old female patient. The presence of the DELC in young women could alert clinicians to the need to further investigate a diagnosis of PCOS. The author is providing an accompanying hypothesis to suggest possible common pathogenesis that links the two to visceral adiposity of the face.
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spelling pubmed-82893982021-07-20 Frank’s Sign in Polycystic Ovary Syndrome and Sideburn Adiposity: A Case Report and Illustrated Hypothesis Abrahim, Mohammed Cureus Endocrinology/Diabetes/Metabolism The diagnosis of polycystic ovary syndrome (PCOS) remains uniquely dependent on physical examination signs. Diagonal earlobe crease (DELC) also referred to as “Frank’s sign, has been associated with several cardiometabolic disorders with further investigations reporting that its occurrence was more prevalent among aging men and thought to a sign of aging skin. However, there is no clear mechanism of development or rationale behind such associations. The author is reporting a novel association between Frank's sign and PCOS in a 23-year-old female patient. The presence of the DELC in young women could alert clinicians to the need to further investigate a diagnosis of PCOS. The author is providing an accompanying hypothesis to suggest possible common pathogenesis that links the two to visceral adiposity of the face. Cureus 2021-06-18 /pmc/articles/PMC8289398/ /pubmed/34290927 http://dx.doi.org/10.7759/cureus.15744 Text en Copyright © 2021, Abrahim et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Endocrinology/Diabetes/Metabolism
Abrahim, Mohammed
Frank’s Sign in Polycystic Ovary Syndrome and Sideburn Adiposity: A Case Report and Illustrated Hypothesis
title Frank’s Sign in Polycystic Ovary Syndrome and Sideburn Adiposity: A Case Report and Illustrated Hypothesis
title_full Frank’s Sign in Polycystic Ovary Syndrome and Sideburn Adiposity: A Case Report and Illustrated Hypothesis
title_fullStr Frank’s Sign in Polycystic Ovary Syndrome and Sideburn Adiposity: A Case Report and Illustrated Hypothesis
title_full_unstemmed Frank’s Sign in Polycystic Ovary Syndrome and Sideburn Adiposity: A Case Report and Illustrated Hypothesis
title_short Frank’s Sign in Polycystic Ovary Syndrome and Sideburn Adiposity: A Case Report and Illustrated Hypothesis
title_sort frank’s sign in polycystic ovary syndrome and sideburn adiposity: a case report and illustrated hypothesis
topic Endocrinology/Diabetes/Metabolism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289398/
https://www.ncbi.nlm.nih.gov/pubmed/34290927
http://dx.doi.org/10.7759/cureus.15744
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