Crosstalk between repair pathways elicits double-strand breaks in alkylated DNA and implications for the action of temozolomide

Temozolomide (TMZ), a DNA methylating agent, is the primary chemotherapeutic drug used in glioblastoma treatment. TMZ induces mostly N-alkylation adducts (N7-methylguanine and N3-methyladenine) and some O(6)-methylguanine (O(6)mG) adducts. Current models propose that during DNA replication, thymine...

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Detalles Bibliográficos
Autores principales: Fuchs, Robert P, Isogawa, Asako, Paulo, Joao A, Onizuka, Kazumitsu, Takahashi, Tatsuro, Amunugama, Ravindra, Duxin, Julien P, Fujii, Shingo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289412/
https://www.ncbi.nlm.nih.gov/pubmed/34236314
http://dx.doi.org/10.7554/eLife.69544

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289412/
https://www.ncbi.nlm.nih.gov/pubmed/34236314
http://dx.doi.org/10.7554/eLife.69544

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