Reduced synchroneity of intra-islet Ca(2+) oscillations in vivo in Robo-deficient β cells

The spatial architecture of the islets of Langerhans is hypothesized to facilitate synchronized insulin secretion among β cells, yet testing this in vivo in the intact pancreas is challenging. Robo βKO mice, in which the genes Robo1 and Robo2 are deleted selectively in β cells, provide a unique mode...

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Detalles Bibliográficos
Autores principales: Adams, Melissa T, Dwulet, JaeAnn M, Briggs, Jennifer K, Reissaus, Christopher A, Jin, Erli, Szulczewski, Joseph M, Lyman, Melissa R, Sdao, Sophia M, Kravets, Vira, Nimkulrat, Sutichot D, Ponik, Suzanne M, Merrins, Matthew J, Mirmira, Raghavendra G, Linnemann, Amelia K, Benninger, Richard KP, Blum, Barak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289414/
https://www.ncbi.nlm.nih.gov/pubmed/34231467
http://dx.doi.org/10.7554/eLife.61308

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