Healthcare workers acquired COVID-19 disease from patients? An investigation by phylogenomics

The increasing number of coronavirus disease 2019 (COVID-19) cases in the community has posed a significant epidemic pressure on healthcare settings. When healthcare workers (HCWs) acquire COVID-19, contact tracing and epidemiological investigation might not be adequate for determining the source of...

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Autores principales: Wong, R.C.W., Lee, M.K.P., Siu, G.K.H., Lee, L.K., Leung, J.S.L., Leung, E.C.M., Ho, Y.I.I., Lai, R.W.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Healthcare Infection Society. Published by Elsevier Ltd. 2021
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289439/
https://www.ncbi.nlm.nih.gov/pubmed/34098050
http://dx.doi.org/10.1016/j.jhin.2021.05.017
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author Wong, R.C.W.
Lee, M.K.P.
Siu, G.K.H.
Lee, L.K.
Leung, J.S.L.
Leung, E.C.M.
Ho, Y.I.I.
Lai, R.W.M.
author_facet Wong, R.C.W.
Lee, M.K.P.
Siu, G.K.H.
Lee, L.K.
Leung, J.S.L.
Leung, E.C.M.
Ho, Y.I.I.
Lai, R.W.M.
author_sort Wong, R.C.W.
collection PubMed
description The increasing number of coronavirus disease 2019 (COVID-19) cases in the community has posed a significant epidemic pressure on healthcare settings. When healthcare workers (HCWs) acquire COVID-19, contact tracing and epidemiological investigation might not be adequate for determining the source of transmission. Here, we report a phylogenetic investigation involving two infected HCWs and nine patients to determine whether patient-to-HCW transmission had occurred in a hospital without a previous COVID-19 outbreak. This is the first study to apply phylogenomics to investigate suspected nosocomial transmission in a region with low prevalence of COVID-19. Our results do not support the occurrence of direct patient-to-HCW transmission.
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spelling pubmed-82894392021-07-20 Healthcare workers acquired COVID-19 disease from patients? An investigation by phylogenomics Wong, R.C.W. Lee, M.K.P. Siu, G.K.H. Lee, L.K. Leung, J.S.L. Leung, E.C.M. Ho, Y.I.I. Lai, R.W.M. J Hosp Infect Short Report The increasing number of coronavirus disease 2019 (COVID-19) cases in the community has posed a significant epidemic pressure on healthcare settings. When healthcare workers (HCWs) acquire COVID-19, contact tracing and epidemiological investigation might not be adequate for determining the source of transmission. Here, we report a phylogenetic investigation involving two infected HCWs and nine patients to determine whether patient-to-HCW transmission had occurred in a hospital without a previous COVID-19 outbreak. This is the first study to apply phylogenomics to investigate suspected nosocomial transmission in a region with low prevalence of COVID-19. Our results do not support the occurrence of direct patient-to-HCW transmission. The Healthcare Infection Society. Published by Elsevier Ltd. 2021-09 2021-07-20 /pmc/articles/PMC8289439/ /pubmed/34098050 http://dx.doi.org/10.1016/j.jhin.2021.05.017 Text en © 2021 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Short Report
Wong, R.C.W.
Lee, M.K.P.
Siu, G.K.H.
Lee, L.K.
Leung, J.S.L.
Leung, E.C.M.
Ho, Y.I.I.
Lai, R.W.M.
Healthcare workers acquired COVID-19 disease from patients? An investigation by phylogenomics
title Healthcare workers acquired COVID-19 disease from patients? An investigation by phylogenomics
title_full Healthcare workers acquired COVID-19 disease from patients? An investigation by phylogenomics
title_fullStr Healthcare workers acquired COVID-19 disease from patients? An investigation by phylogenomics
title_full_unstemmed Healthcare workers acquired COVID-19 disease from patients? An investigation by phylogenomics
title_short Healthcare workers acquired COVID-19 disease from patients? An investigation by phylogenomics
title_sort healthcare workers acquired covid-19 disease from patients? an investigation by phylogenomics
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289439/
https://www.ncbi.nlm.nih.gov/pubmed/34098050
http://dx.doi.org/10.1016/j.jhin.2021.05.017
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