Cargando…

Prediction of Srebp-1 as a Key Target of Qing Gan San Against MAFLD in Rats via RNA-Sequencing Profile Analysis

Metabolism-associated fatty liver disease (MAFLD) is the most common chronic liver disease worldwide, and the use of traditional Chinese medicines (TCMs) to treat this disease has attracted increasing attention. The Qing Gan San (QGS) formula comprises Polygonatum sibiricum, the peel of Citrus retic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Bendong, Sun, Jingyue, Liang, Shufei, Wu, Peixuan, Lv, Rui, He, Yanping, Li, Deqi, Sun, Wenlong, Song, Xinhua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289482/ https://www.ncbi.nlm.nih.gov/pubmed/34290609 http://dx.doi.org/10.3389/fphar.2021.680081

Ejemplares similares

Attenuating effect of Polygala tenuifolia Willd. seed oil on progression of MAFLD
por: Xin, Meiling, et al.
Publicado: (2023)

Network pharmacology analysis to explore mechanism of Three Flower Tea against nonalcoholic fatty liver disease with experimental support using high-fat diet-induced rats
por: Wu, Peixuan, et al.
Publicado: (2022)

Broad Anti-Viral Capacities of Lian-Hua-Qing-Wen Capsule and Jin-Hua-Qing-Gan Granule and Rational use Against COVID-19 Based on Literature Mining
por: Shi, Mingfei, et al.
Publicado: (2021)

Key events in cancer: Dysregulation of SREBPs
por: Li, Yunkuo, et al.
Publicado: (2023)

New insight into the management of renal excretion and hyperuricemia: Potential therapeutic strategies with natural bioactive compounds
por: Yang, Bendong, et al.
Publicado: (2022)

Computational Network Pharmacology–Based Strategy to Capture Key Functional Components and Decode the Mechanism of Chai-Hu-Shu-Gan-San in Treating Depression
por: Wang, Kexin, et al.
Publicado: (2021)

An Ethnobotanical Study on Qīng-Căo-Chá Tea in Taiwan
por: Huang, Shyh-Shyun, et al.
Publicado: (2020)

Si-Wei-Qing-Gan-Tang Improves Non-Alcoholic Steatohepatitis by Modulating the Nuclear Factor-κB Signal Pathway and Autophagy in Methionine and Choline Deficient Diet-Fed Rats
por: Xiao, Lingyun, et al.
Publicado: (2020)

Emodin Induced SREBP1-Dependent and SREBP1-Independent Apoptosis in Hepatocellular Carcinoma Cells
por: Yang, Nian, et al.
Publicado: (2019)

Network Pharmacology-Based Validation of Caveolin-1 as a Key Mediator of Ai Du Qing Inhibition of Drug Resistance in Breast Cancer
por: Wang, Neng, et al.
Publicado: (2018)

The IDI1/SREBP2 axis drives intrahepatic cholestasis and is a treatment target of San-Huang-Cai-Zhu formula identified by sequencing and experiments
por: Yan, Junbin, et al.
Publicado: (2023)

Qing-Kai-Ling Injection Induces Immediate Hypersensitivity Reaction via the Activation of Anaphylatoxin C3
por: Gao, Yuan, et al.
Publicado: (2020)

Activation of Autophagy Through the NLRP3/mTOR Pathway: A Potential Mechanism for Alleviation of Pneumonia by QingFei Yin
por: Sun, Xiaozhou, et al.
Publicado: (2022)

Yishen Qingli Heluo Granule Ameliorates Renal Dysfunction in 5/6 Nephrectomized Rats by Targeting Gut Microbiota and Intestinal Barrier Integrity
por: Sun, Xian, et al.
Publicado: (2022)

Gut Microbiota Is the Key to the Antidepressant Effect of Chaihu-Shu-Gan-San
por: Yu, Meng, et al.
Publicado: (2020)

Hu-Zhang-Qing-Mai-Yin Inhibits Proliferation of Human Retinal Capillary Endothelial Cells Exposed to High Glucose
por: Yu, Yuan-Yuan, et al.
Publicado: (2021)

Qing-Re-Xiao-Zheng-Yi-Qi formula relieves kidney damage and activates mitophagy in diabetic kidney disease
por: Wu, Qiaoru, et al.
Publicado: (2022)

Network Pharmacology and Experimental Validation to Explore the Mechanism of Qing-Jin-Hua-Tan-Decoction Against Acute Lung Injury
por: Xiao, Shunli, et al.
Publicado: (2022)

A novel small compound TOIDC suppresses lipogenesis via SREBP1-dependent signaling to curb MAFLD
por: Shao, Yaodi, et al.
Publicado: (2022)

Qing-Yi Decoction in the Treatment of Acute Pancreatitis: An Integrated Approach Based on Chemical Profile, Network Pharmacology, Molecular Docking and Experimental Evaluation
por: Wei, Tian-Fu, et al.
Publicado: (2021)

Modified Qing’e Formula protects against UV-induced skin oxidative damage via the activation of Nrf2/ARE defensive pathway
por: Zhu, Shan, et al.
Publicado: (2022)

Qing Hua Chang Yin alleviates chronic colitis of mice by protecting intestinal barrier function and improving colonic microflora
por: Han, Yuying, et al.
Publicado: (2023)

Sex-Related Differences of Lipid Metabolism Induced by Triptolide: The Possible Role of the LXRα/SREBP-1 Signaling Pathway
por: Jiang, Zhenzhou, et al.
Publicado: (2016)

Lian Hua Qing Wen Capsules, a Potent Epithelial Protector in Acute Lung Injury Model, Block Proapoptotic Communication Between Macrophages, and Alveolar Epithelial Cells
por: Li, Qi, et al.
Publicado: (2020)

Integrating Network Pharmacology and Metabolomics Study on Anti-rheumatic Mechanisms and Antagonistic Effects Against Methotrexate-Induced Toxicity of Qing-Luo-Yin
por: Zuo, Jian, et al.
Publicado: (2018)

Mechanism of Anti-Inflammatory and Antibacterial Effects of QingXiaoWuWei Decoction Based on Network Pharmacology, Molecular Docking and In Vitro Experiments
por: Zhang, Qian, et al.
Publicado: (2021)

Recent Insights Into SREBP as a Direct Mediator of Kidney Fibrosis via Lipid-Independent Pathways
por: Dorotea, Debra, et al.
Publicado: (2020)

Qing-Wen-Jie-Re Mixture Ameliorates Poly (I:C)-Induced Viral Pneumonia Through Regulating the Inflammatory Response and Serum Metabolism
por: Li, Qin, et al.
Publicado: (2022)

A Novel Small-Molecule Inhibitor of SREBP-1 Based on Natural Product Monomers Upregulates the Sensitivity of Lung Squamous Cell Carcinoma Cells to Antitumor Drugs
por: Ma, De-Bin, et al.
Publicado: (2022)

Mechanisms of Qing-Gan Li-Shui Formulation in Ameliorating Primary Open Angle Glaucoma: An Analysis Based on Network Pharmacology
por: Mu, Lin, et al.
Publicado: (2022)

Qing`e Pill Inhibits Osteoblast Ferroptosis via ATM Serine/Threonine Kinase (ATM) and the PI3K/AKT Pathway in Primary Osteoporosis
por: Hao, Jian, et al.
Publicado: (2022)

Network pharmacology, molecular docking, and experimental validation to explore the potential mechanism of Long Mu Qing Xin mixture for the treatment of attention deficit hyperactivity disorder
por: Li, Xuejun, et al.
Publicado: (2023)

Autophagy Blockade by Ai Du Qing Formula Promotes Chemosensitivity of Breast Cancer Stem Cells Via GRP78/β-Catenin/ABCG2 Axis
por: Liao, Mianmian, et al.
Publicado: (2021)

Gut Microbiota and SCFAs Play Key Roles in QingFei Yin Recipe Anti-Streptococcal Pneumonia Effects
por: Sun, Xiaozhou, et al.
Publicado: (2021)

Comparison of pharmacokinetic profiles of seven major bioactive components in normal and non-alcoholic fatty liver disease (NAFLD) rats after oral administration of Ling-Gui-Zhu-Gan decoction by UPLC-MS/MS
por: Nie, Wenlong, et al.
Publicado: (2023)

Corrigendum: Autophagy Blockade by Ai Du Qing Formula Promotes Chemosensitivity of Breast Cancer Stem Cells Via GRP78/β-Catenin/ABCG2 Axis
por: Liao, Mianmian, et al.
Publicado: (2022)

Anti-endometriosis Mechanism of Jiawei Foshou San Based on Network Pharmacology
por: Chen, Yi, et al.
Publicado: (2018)

Jian Pi Tiao Gan Yin alleviates obesity phenotypes through mTORC1/SREBP1 signaling in vitro and in vivo
por: Song, Xiaoming, et al.
Publicado: (2022)

Di’ao Xinxuekang Capsule Improves the Anti-Atherosclerotic Effect of Atorvastatin by Downregulating the SREBP2/PCSK9 Signalling Pathway
por: Liang, Jiyi, et al.
Publicado: (2022)

Effects of Poria cocos extract on metabolic dysfunction-associated fatty liver disease via the FXR/PPARα-SREBPs pathway
por: He, Jinbiao, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_i19svmcc79k3qqdcdpch32v2no