Hair Cell Protection from Ototoxic Drugs

Hearing loss is often caused by death of sensory hair cells (HCs) in the inner ear. HCs are vulnerable to some ototoxic drugs, such as aminoglycosides(AGs) and the cisplatin.The most predominant form of drug-induced cell death is apoptosis. Many efforts have been made to protect HCs from cell death...

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Detalles Bibliográficos
Autores principales: Wu, Peng, Wu, Xianmin, Zhang, Chunhong, Chen, Xiaoyun, Huang, Yideng, Li, He
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289577/
https://www.ncbi.nlm.nih.gov/pubmed/34335732
http://dx.doi.org/10.1155/2021/4909237
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author Wu, Peng
Wu, Xianmin
Zhang, Chunhong
Chen, Xiaoyun
Huang, Yideng
Li, He
author_facet Wu, Peng
Wu, Xianmin
Zhang, Chunhong
Chen, Xiaoyun
Huang, Yideng
Li, He
author_sort Wu, Peng
collection PubMed
description Hearing loss is often caused by death of sensory hair cells (HCs) in the inner ear. HCs are vulnerable to some ototoxic drugs, such as aminoglycosides(AGs) and the cisplatin.The most predominant form of drug-induced cell death is apoptosis. Many efforts have been made to protect HCs from cell death after ototoxic drug exposure. These mechanisms and potential targets of HCs protection will be discussed in this review.And we also propose further investigation in the field of HCs necrosis and regeneration, as well as future clinical utilization.
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spelling pubmed-82895772021-07-31 Hair Cell Protection from Ototoxic Drugs Wu, Peng Wu, Xianmin Zhang, Chunhong Chen, Xiaoyun Huang, Yideng Li, He Neural Plast Review Article Hearing loss is often caused by death of sensory hair cells (HCs) in the inner ear. HCs are vulnerable to some ototoxic drugs, such as aminoglycosides(AGs) and the cisplatin.The most predominant form of drug-induced cell death is apoptosis. Many efforts have been made to protect HCs from cell death after ototoxic drug exposure. These mechanisms and potential targets of HCs protection will be discussed in this review.And we also propose further investigation in the field of HCs necrosis and regeneration, as well as future clinical utilization. Hindawi 2021-07-11 /pmc/articles/PMC8289577/ /pubmed/34335732 http://dx.doi.org/10.1155/2021/4909237 Text en Copyright © 2021 Peng Wu et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wu, Peng
Wu, Xianmin
Zhang, Chunhong
Chen, Xiaoyun
Huang, Yideng
Li, He
Hair Cell Protection from Ototoxic Drugs
title Hair Cell Protection from Ototoxic Drugs
title_full Hair Cell Protection from Ototoxic Drugs
title_fullStr Hair Cell Protection from Ototoxic Drugs
title_full_unstemmed Hair Cell Protection from Ototoxic Drugs
title_short Hair Cell Protection from Ototoxic Drugs
title_sort hair cell protection from ototoxic drugs
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289577/
https://www.ncbi.nlm.nih.gov/pubmed/34335732
http://dx.doi.org/10.1155/2021/4909237
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AT chenxiaoyun haircellprotectionfromototoxicdrugs
AT huangyideng haircellprotectionfromototoxicdrugs
AT lihe haircellprotectionfromototoxicdrugs

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