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Reduced TGF-β Expression and CD206-Positive Resident Macrophages in the Intervertebral Discs of Aged Mice
Age is a key factor in intervertebral disc (IVD) degeneration; however, the changes that occur in IVDs with age are not fully understood. Tissue-resident macrophages are critical for tissue homeostasis and are regulated by transforming growth factor- (TGF-) β. We examined changes in the proportion o...
Autores principales: | Yokozeki, Yuji, Kawakubo, Ayumu, Miyagi, Masayuki, Kuroda, Akiyoshi, Sekiguchi, Hiroyuki, Inoue, Gen, Takaso, Masashi, Uchida, Kentaro |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289593/ https://www.ncbi.nlm.nih.gov/pubmed/34337052 http://dx.doi.org/10.1155/2021/7988320 |
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