Support of BCP-ALL-cells by autologous bone marrow Th-cells involves induction of AID expression but not widespread AID off-target mutagenesis

B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is the most common childhood malignancy. The two-step BCP-ALL pathogenesis requires in utero-induced chromosomal aberrations and additional mutagenic events for overt leukemia. In mouse models, activation-induced cytidine deaminase (AID/AICDA)...

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Detalles Bibliográficos
Autores principales: Traxel, Sabrina, Lehmann, Julia, Richard, Stefanie, Sidorov, Semjon, Niggli, Felix, Berger, Christoph, Nadal, David, Bürgler, Simone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289808/
https://www.ncbi.nlm.nih.gov/pubmed/33507341
http://dx.doi.org/10.1007/s00262-020-02835-x

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