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SARS-CoV-2 antibody dynamics and transmission from community-wide serological testing in the Italian municipality of Vo’
In February and March 2020, two mass swab testing campaigns were conducted in Vo’, Italy. In May 2020, we tested 86% of the Vo’ population with three immuno-assays detecting antibodies against the spike and nucleocapsid antigens, a neutralisation assay and Polymerase Chain Reaction (PCR). Subjects t...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289856/ https://www.ncbi.nlm.nih.gov/pubmed/34282139 http://dx.doi.org/10.1038/s41467-021-24622-7 |
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| author | Dorigatti, Ilaria Lavezzo, Enrico Manuto, Laura Ciavarella, Constanze Pacenti, Monia Boldrin, Caterina Cattai, Margherita Saluzzo, Francesca Franchin, Elisa Del Vecchio, Claudia Caldart, Federico Castelli, Gioele Nicoletti, Michele Nieddu, Eleonora Salvadoretti, Elisa Labella, Beatrice Fava, Ludovico Guglielmo, Simone Fascina, Mariateresa Grazioli, Marco Alvisi, Gualtiero Vanuzzo, Maria Cristina Zupo, Tiziano Calandrin, Reginetta Lisi, Vittoria Rossi, Lucia Castagliuolo, Ignazio Merigliano, Stefano Unwin, H. Juliette T. Plebani, Mario Padoan, Andrea Brazzale, Alessandra R. Toppo, Stefano Ferguson, Neil M. Donnelly, Christl A. Crisanti, Andrea |
| author_facet | Dorigatti, Ilaria Lavezzo, Enrico Manuto, Laura Ciavarella, Constanze Pacenti, Monia Boldrin, Caterina Cattai, Margherita Saluzzo, Francesca Franchin, Elisa Del Vecchio, Claudia Caldart, Federico Castelli, Gioele Nicoletti, Michele Nieddu, Eleonora Salvadoretti, Elisa Labella, Beatrice Fava, Ludovico Guglielmo, Simone Fascina, Mariateresa Grazioli, Marco Alvisi, Gualtiero Vanuzzo, Maria Cristina Zupo, Tiziano Calandrin, Reginetta Lisi, Vittoria Rossi, Lucia Castagliuolo, Ignazio Merigliano, Stefano Unwin, H. Juliette T. Plebani, Mario Padoan, Andrea Brazzale, Alessandra R. Toppo, Stefano Ferguson, Neil M. Donnelly, Christl A. Crisanti, Andrea |
| author_sort | Dorigatti, Ilaria |
| collection | PubMed |
| description | In February and March 2020, two mass swab testing campaigns were conducted in Vo’, Italy. In May 2020, we tested 86% of the Vo’ population with three immuno-assays detecting antibodies against the spike and nucleocapsid antigens, a neutralisation assay and Polymerase Chain Reaction (PCR). Subjects testing positive to PCR in February/March or a serological assay in May were tested again in November. Here we report on the results of the analysis of the May and November surveys. We estimate a seroprevalence of 3.5% (95% Credible Interval (CrI): 2.8–4.3%) in May. In November, 98.8% (95% Confidence Interval (CI): 93.7–100.0%) of sera which tested positive in May still reacted against at least one antigen; 18.6% (95% CI: 11.0–28.5%) showed an increase of antibody or neutralisation reactivity from May. Analysis of the serostatus of the members of 1,118 households indicates a 26.0% (95% CrI: 17.2–36.9%) Susceptible-Infectious Transmission Probability. Contact tracing had limited impact on epidemic suppression. |
| format | Online Article Text |
| id | pubmed-8289856 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-82898562021-07-23 SARS-CoV-2 antibody dynamics and transmission from community-wide serological testing in the Italian municipality of Vo’ Dorigatti, Ilaria Lavezzo, Enrico Manuto, Laura Ciavarella, Constanze Pacenti, Monia Boldrin, Caterina Cattai, Margherita Saluzzo, Francesca Franchin, Elisa Del Vecchio, Claudia Caldart, Federico Castelli, Gioele Nicoletti, Michele Nieddu, Eleonora Salvadoretti, Elisa Labella, Beatrice Fava, Ludovico Guglielmo, Simone Fascina, Mariateresa Grazioli, Marco Alvisi, Gualtiero Vanuzzo, Maria Cristina Zupo, Tiziano Calandrin, Reginetta Lisi, Vittoria Rossi, Lucia Castagliuolo, Ignazio Merigliano, Stefano Unwin, H. Juliette T. Plebani, Mario Padoan, Andrea Brazzale, Alessandra R. Toppo, Stefano Ferguson, Neil M. Donnelly, Christl A. Crisanti, Andrea Nat Commun Article In February and March 2020, two mass swab testing campaigns were conducted in Vo’, Italy. In May 2020, we tested 86% of the Vo’ population with three immuno-assays detecting antibodies against the spike and nucleocapsid antigens, a neutralisation assay and Polymerase Chain Reaction (PCR). Subjects testing positive to PCR in February/March or a serological assay in May were tested again in November. Here we report on the results of the analysis of the May and November surveys. We estimate a seroprevalence of 3.5% (95% Credible Interval (CrI): 2.8–4.3%) in May. In November, 98.8% (95% Confidence Interval (CI): 93.7–100.0%) of sera which tested positive in May still reacted against at least one antigen; 18.6% (95% CI: 11.0–28.5%) showed an increase of antibody or neutralisation reactivity from May. Analysis of the serostatus of the members of 1,118 households indicates a 26.0% (95% CrI: 17.2–36.9%) Susceptible-Infectious Transmission Probability. Contact tracing had limited impact on epidemic suppression. Nature Publishing Group UK 2021-07-19 /pmc/articles/PMC8289856/ /pubmed/34282139 http://dx.doi.org/10.1038/s41467-021-24622-7 Text en © The Author(s) 2021, corrected publication 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Article Dorigatti, Ilaria Lavezzo, Enrico Manuto, Laura Ciavarella, Constanze Pacenti, Monia Boldrin, Caterina Cattai, Margherita Saluzzo, Francesca Franchin, Elisa Del Vecchio, Claudia Caldart, Federico Castelli, Gioele Nicoletti, Michele Nieddu, Eleonora Salvadoretti, Elisa Labella, Beatrice Fava, Ludovico Guglielmo, Simone Fascina, Mariateresa Grazioli, Marco Alvisi, Gualtiero Vanuzzo, Maria Cristina Zupo, Tiziano Calandrin, Reginetta Lisi, Vittoria Rossi, Lucia Castagliuolo, Ignazio Merigliano, Stefano Unwin, H. Juliette T. Plebani, Mario Padoan, Andrea Brazzale, Alessandra R. Toppo, Stefano Ferguson, Neil M. Donnelly, Christl A. Crisanti, Andrea SARS-CoV-2 antibody dynamics and transmission from community-wide serological testing in the Italian municipality of Vo’ |
| title | SARS-CoV-2 antibody dynamics and transmission from community-wide serological testing in the Italian municipality of Vo’ |
| title_full | SARS-CoV-2 antibody dynamics and transmission from community-wide serological testing in the Italian municipality of Vo’ |
| title_fullStr | SARS-CoV-2 antibody dynamics and transmission from community-wide serological testing in the Italian municipality of Vo’ |
| title_full_unstemmed | SARS-CoV-2 antibody dynamics and transmission from community-wide serological testing in the Italian municipality of Vo’ |
| title_short | SARS-CoV-2 antibody dynamics and transmission from community-wide serological testing in the Italian municipality of Vo’ |
| title_sort | sars-cov-2 antibody dynamics and transmission from community-wide serological testing in the italian municipality of vo’ |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289856/ https://www.ncbi.nlm.nih.gov/pubmed/34282139 http://dx.doi.org/10.1038/s41467-021-24622-7 |
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