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Neuroplastin in human cognition: review of literature and future perspectives
Synaptic glycoprotein neuroplastin is involved in synaptic plasticity and complex molecular events underlying learning and memory. Studies in mice and rats suggest that neuroplastin is essential for cognition, as it is needed for long-term potentiation and associative memory formation. Recently, it...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289873/ https://www.ncbi.nlm.nih.gov/pubmed/34282131 http://dx.doi.org/10.1038/s41398-021-01509-1 |
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author | Ilic, Katarina Mlinac-Jerkovic, Kristina Sedmak, Goran Rosenzweig, Ivana Kalanj-Bognar, Svjetlana |
author_facet | Ilic, Katarina Mlinac-Jerkovic, Kristina Sedmak, Goran Rosenzweig, Ivana Kalanj-Bognar, Svjetlana |
author_sort | Ilic, Katarina |
collection | PubMed |
description | Synaptic glycoprotein neuroplastin is involved in synaptic plasticity and complex molecular events underlying learning and memory. Studies in mice and rats suggest that neuroplastin is essential for cognition, as it is needed for long-term potentiation and associative memory formation. Recently, it was found that some of the effects of neuroplastin are related to regulation of calcium homeostasis through interactions with plasma membrane calcium ATPases. Neuroplastin is increasingly seen as a key factor in complex brain functions, but studies in humans remain scarce. Here we summarize present knowledge about neuroplastin in human tissues and argue its genetic association with cortical thickness, intelligence, schizophrenia, and autism; specific immunolocalization depicting hippocampal trisynaptic pathway; potential role in tissue compensatory response in neurodegeneration; and high, almost housekeeping, level of spatio-temporal gene expression in the human brain. We also propose that neuroplastin acts as a housekeeper of neuroplasticity, and that it may be considered as an important novel cognition-related molecule in humans. Several promising directions for future investigations are suggested, which may complete our understanding of neuroplastin actions in molecular basis of human cognition. [Image: see text] |
format | Online Article Text |
id | pubmed-8289873 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-82898732021-07-23 Neuroplastin in human cognition: review of literature and future perspectives Ilic, Katarina Mlinac-Jerkovic, Kristina Sedmak, Goran Rosenzweig, Ivana Kalanj-Bognar, Svjetlana Transl Psychiatry Perspective Synaptic glycoprotein neuroplastin is involved in synaptic plasticity and complex molecular events underlying learning and memory. Studies in mice and rats suggest that neuroplastin is essential for cognition, as it is needed for long-term potentiation and associative memory formation. Recently, it was found that some of the effects of neuroplastin are related to regulation of calcium homeostasis through interactions with plasma membrane calcium ATPases. Neuroplastin is increasingly seen as a key factor in complex brain functions, but studies in humans remain scarce. Here we summarize present knowledge about neuroplastin in human tissues and argue its genetic association with cortical thickness, intelligence, schizophrenia, and autism; specific immunolocalization depicting hippocampal trisynaptic pathway; potential role in tissue compensatory response in neurodegeneration; and high, almost housekeeping, level of spatio-temporal gene expression in the human brain. We also propose that neuroplastin acts as a housekeeper of neuroplasticity, and that it may be considered as an important novel cognition-related molecule in humans. Several promising directions for future investigations are suggested, which may complete our understanding of neuroplastin actions in molecular basis of human cognition. [Image: see text] Nature Publishing Group UK 2021-07-16 /pmc/articles/PMC8289873/ /pubmed/34282131 http://dx.doi.org/10.1038/s41398-021-01509-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Perspective Ilic, Katarina Mlinac-Jerkovic, Kristina Sedmak, Goran Rosenzweig, Ivana Kalanj-Bognar, Svjetlana Neuroplastin in human cognition: review of literature and future perspectives |
title | Neuroplastin in human cognition: review of literature and future perspectives |
title_full | Neuroplastin in human cognition: review of literature and future perspectives |
title_fullStr | Neuroplastin in human cognition: review of literature and future perspectives |
title_full_unstemmed | Neuroplastin in human cognition: review of literature and future perspectives |
title_short | Neuroplastin in human cognition: review of literature and future perspectives |
title_sort | neuroplastin in human cognition: review of literature and future perspectives |
topic | Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289873/ https://www.ncbi.nlm.nih.gov/pubmed/34282131 http://dx.doi.org/10.1038/s41398-021-01509-1 |
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