Risperidone Mitigates Enhanced Excitatory Neuronal Function and Repetitive Behavior Caused by an ASD-Associated Mutation of SIK1

Six mutations in the salt-inducible kinase 1 (SIK1)-coding gene have been identified in patients with early infantile epileptic encephalopathy (EIEE-30) accompanied by autistic symptoms. Two of the mutations are non-sense mutations that truncate the C-terminal region of SIK1. It has been shown that...

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Detalles Bibliográficos
Autores principales: Badawi, Moataz, Mori, Takuma, Kurihara, Taiga, Yoshizawa, Takahiro, Nohara, Katsuhiro, Kouyama-Suzuki, Emi, Yanagawa, Toru, Shirai, Yoshinori, Tabuchi, Katsuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289890/
https://www.ncbi.nlm.nih.gov/pubmed/34295222
http://dx.doi.org/10.3389/fnmol.2021.706494

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