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Metabolic factors and the risk of Dupuytren’s disease: data from 30,000 individuals followed for over 20 years

Dupuytren’s disease (DD) is a fibroproliferative disorder affecting the palmar fascia of the hand. Risk factors include diabetes mellitus (DM), whereas a high body mass index (BMI) is associated with a lower prevalence of DD. The aim of this study was to further elucidate risk and protective factors...

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Autores principales: Rydberg, Mattias, Zimmerman, Malin, Löfgren, Jin Persson, Gottsäter, Anders, Nilsson, Peter M., Melander, Olle, Dahlin, Lars B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289914/
https://www.ncbi.nlm.nih.gov/pubmed/34282190
http://dx.doi.org/10.1038/s41598-021-94025-7
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author Rydberg, Mattias
Zimmerman, Malin
Löfgren, Jin Persson
Gottsäter, Anders
Nilsson, Peter M.
Melander, Olle
Dahlin, Lars B.
author_facet Rydberg, Mattias
Zimmerman, Malin
Löfgren, Jin Persson
Gottsäter, Anders
Nilsson, Peter M.
Melander, Olle
Dahlin, Lars B.
author_sort Rydberg, Mattias
collection PubMed
description Dupuytren’s disease (DD) is a fibroproliferative disorder affecting the palmar fascia of the hand. Risk factors include diabetes mellitus (DM), whereas a high body mass index (BMI) is associated with a lower prevalence of DD. The aim of this study was to further elucidate risk and protective factors for the development of DD using longitudinal population-based data from the Malmö Diet and Cancer Study (MDCS). During 1991–1996, the inhabitants aged 46–73 years in the city of Malmö, Sweden were invited to participate in the population-based MDCS (41% participation rate). Data on incident DD were retrieved from Swedish national registers. Associations between DM, alcohol consumption, BMI, and serum apolipoprotein A1 (ApoA1) and apolipoprotein B (ApoB) at baseline were analysed in multivariable Cox regression models adjusted for known confounders. Among 30,446 recruited participants, 347 men and 194 women were diagnosed with DD during a median follow-up time of 23 years. DM (men HR 2.23; 95% CI 1.50–3.30, women HR 2.69; 95% CI 1.48–4.90) and alcohol consumption (men HR 2.46; 95% CI 1.85–3.27, women HR 3.56; 95% CI 1.95–6.50) were independently associated with incident DD in the Cox regression models. Furthermore, inverse associations with incident DD were found for obesity among men, and ApoB/ApoA1 ratio among both sexes. DM and excess alcohol consumption constituted major risk factors for the development of DD. Furthermore, an inverse association between obesity among men and DD, and also between ApoB/ApoA1 ratio and DD was found in both sexes.
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spelling pubmed-82899142021-07-21 Metabolic factors and the risk of Dupuytren’s disease: data from 30,000 individuals followed for over 20 years Rydberg, Mattias Zimmerman, Malin Löfgren, Jin Persson Gottsäter, Anders Nilsson, Peter M. Melander, Olle Dahlin, Lars B. Sci Rep Article Dupuytren’s disease (DD) is a fibroproliferative disorder affecting the palmar fascia of the hand. Risk factors include diabetes mellitus (DM), whereas a high body mass index (BMI) is associated with a lower prevalence of DD. The aim of this study was to further elucidate risk and protective factors for the development of DD using longitudinal population-based data from the Malmö Diet and Cancer Study (MDCS). During 1991–1996, the inhabitants aged 46–73 years in the city of Malmö, Sweden were invited to participate in the population-based MDCS (41% participation rate). Data on incident DD were retrieved from Swedish national registers. Associations between DM, alcohol consumption, BMI, and serum apolipoprotein A1 (ApoA1) and apolipoprotein B (ApoB) at baseline were analysed in multivariable Cox regression models adjusted for known confounders. Among 30,446 recruited participants, 347 men and 194 women were diagnosed with DD during a median follow-up time of 23 years. DM (men HR 2.23; 95% CI 1.50–3.30, women HR 2.69; 95% CI 1.48–4.90) and alcohol consumption (men HR 2.46; 95% CI 1.85–3.27, women HR 3.56; 95% CI 1.95–6.50) were independently associated with incident DD in the Cox regression models. Furthermore, inverse associations with incident DD were found for obesity among men, and ApoB/ApoA1 ratio among both sexes. DM and excess alcohol consumption constituted major risk factors for the development of DD. Furthermore, an inverse association between obesity among men and DD, and also between ApoB/ApoA1 ratio and DD was found in both sexes. Nature Publishing Group UK 2021-07-19 /pmc/articles/PMC8289914/ /pubmed/34282190 http://dx.doi.org/10.1038/s41598-021-94025-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Rydberg, Mattias
Zimmerman, Malin
Löfgren, Jin Persson
Gottsäter, Anders
Nilsson, Peter M.
Melander, Olle
Dahlin, Lars B.
Metabolic factors and the risk of Dupuytren’s disease: data from 30,000 individuals followed for over 20 years
title Metabolic factors and the risk of Dupuytren’s disease: data from 30,000 individuals followed for over 20 years
title_full Metabolic factors and the risk of Dupuytren’s disease: data from 30,000 individuals followed for over 20 years
title_fullStr Metabolic factors and the risk of Dupuytren’s disease: data from 30,000 individuals followed for over 20 years
title_full_unstemmed Metabolic factors and the risk of Dupuytren’s disease: data from 30,000 individuals followed for over 20 years
title_short Metabolic factors and the risk of Dupuytren’s disease: data from 30,000 individuals followed for over 20 years
title_sort metabolic factors and the risk of dupuytren’s disease: data from 30,000 individuals followed for over 20 years
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289914/
https://www.ncbi.nlm.nih.gov/pubmed/34282190
http://dx.doi.org/10.1038/s41598-021-94025-7
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