The effect of eligibility for antiretroviral therapy on body mass index and blood pressure in KwaZulu-Natal, South Africa

We use a regression discontinuity design to estimate the causal effect of antiretroviral therapy (ART) eligibility according to national treatment guidelines of South Africa on two risk factors for cardiovascular disease, body mass index (BMI) and blood pressure. We combine survey data collected in...

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Autores principales: Kuber, Aditi, Reuter, Anna, Geldsetzer, Pascal, Chimbindi, Natsayi, Moshabela, Mosa, Tanser, Frank, Bärnighausen, Till, Vollmer, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289961/
https://www.ncbi.nlm.nih.gov/pubmed/34282184
http://dx.doi.org/10.1038/s41598-021-94057-z
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author Kuber, Aditi
Reuter, Anna
Geldsetzer, Pascal
Chimbindi, Natsayi
Moshabela, Mosa
Tanser, Frank
Bärnighausen, Till
Vollmer, Sebastian
author_facet Kuber, Aditi
Reuter, Anna
Geldsetzer, Pascal
Chimbindi, Natsayi
Moshabela, Mosa
Tanser, Frank
Bärnighausen, Till
Vollmer, Sebastian
author_sort Kuber, Aditi
collection PubMed
description We use a regression discontinuity design to estimate the causal effect of antiretroviral therapy (ART) eligibility according to national treatment guidelines of South Africa on two risk factors for cardiovascular disease, body mass index (BMI) and blood pressure. We combine survey data collected in 2010 in KwaZulu-Natal, South Africa, with clinical data on ART. We find that early ART eligibility significantly reduces systolic and diastolic blood pressure. We do not find any significant effects on BMI. The effect on blood pressure can be detected up to three years after becoming eligible for ART.
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spelling pubmed-82899612021-07-21 The effect of eligibility for antiretroviral therapy on body mass index and blood pressure in KwaZulu-Natal, South Africa Kuber, Aditi Reuter, Anna Geldsetzer, Pascal Chimbindi, Natsayi Moshabela, Mosa Tanser, Frank Bärnighausen, Till Vollmer, Sebastian Sci Rep Article We use a regression discontinuity design to estimate the causal effect of antiretroviral therapy (ART) eligibility according to national treatment guidelines of South Africa on two risk factors for cardiovascular disease, body mass index (BMI) and blood pressure. We combine survey data collected in 2010 in KwaZulu-Natal, South Africa, with clinical data on ART. We find that early ART eligibility significantly reduces systolic and diastolic blood pressure. We do not find any significant effects on BMI. The effect on blood pressure can be detected up to three years after becoming eligible for ART. Nature Publishing Group UK 2021-07-19 /pmc/articles/PMC8289961/ /pubmed/34282184 http://dx.doi.org/10.1038/s41598-021-94057-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Kuber, Aditi
Reuter, Anna
Geldsetzer, Pascal
Chimbindi, Natsayi
Moshabela, Mosa
Tanser, Frank
Bärnighausen, Till
Vollmer, Sebastian
The effect of eligibility for antiretroviral therapy on body mass index and blood pressure in KwaZulu-Natal, South Africa
title The effect of eligibility for antiretroviral therapy on body mass index and blood pressure in KwaZulu-Natal, South Africa
title_full The effect of eligibility for antiretroviral therapy on body mass index and blood pressure in KwaZulu-Natal, South Africa
title_fullStr The effect of eligibility for antiretroviral therapy on body mass index and blood pressure in KwaZulu-Natal, South Africa
title_full_unstemmed The effect of eligibility for antiretroviral therapy on body mass index and blood pressure in KwaZulu-Natal, South Africa
title_short The effect of eligibility for antiretroviral therapy on body mass index and blood pressure in KwaZulu-Natal, South Africa
title_sort effect of eligibility for antiretroviral therapy on body mass index and blood pressure in kwazulu-natal, south africa
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289961/
https://www.ncbi.nlm.nih.gov/pubmed/34282184
http://dx.doi.org/10.1038/s41598-021-94057-z
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