A Cdk4/6-dependent phosphorylation gradient regulates the early to late G1 phase transition

During early G1 phase, Rb is exclusively mono-phosphorylated by cyclin D:Cdk4/6, generating 14 different isoforms with specific binding patterns to E2Fs and other cellular protein targets. While mono-phosphorylated Rb is dispensable for early G1 phase progression, interfering with cyclin D:Cdk4/6 ki...

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Detalles Bibliográficos
Autores principales: Kaulich, Manuel, Link, Verena M., Lapek, John D., Lee, Yeon J., Glass, Christopher K., Gonzalez, David J., Dowdy, Steven F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8290049/
https://www.ncbi.nlm.nih.gov/pubmed/34282211
http://dx.doi.org/10.1038/s41598-021-94200-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8290049/
https://www.ncbi.nlm.nih.gov/pubmed/34282211
http://dx.doi.org/10.1038/s41598-021-94200-w

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