Effects of Lipopolysaccharide-Binding Protein (LBP) Single Nucleotide Polymorphism (SNP) in Infections, Inflammatory Diseases, Metabolic Disorders and Cancers

Inflammation, which is induced by the immune response, is recognized as the driving factor in many diseases, including infections and inflammatory diseases, metabolic disorders and cancers. Genetic variations in pivotal genes associated with the immune response, particularly single nucleotide polymo...

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Autores principales: Meng, Leilei, Song, Zichen, Liu, Anding, Dahmen, Uta, Yang, Xiao, Fang, Haoshu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8290185/
https://www.ncbi.nlm.nih.gov/pubmed/34295331
http://dx.doi.org/10.3389/fimmu.2021.681810
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author Meng, Leilei
Song, Zichen
Liu, Anding
Dahmen, Uta
Yang, Xiao
Fang, Haoshu
author_facet Meng, Leilei
Song, Zichen
Liu, Anding
Dahmen, Uta
Yang, Xiao
Fang, Haoshu
author_sort Meng, Leilei
collection PubMed
description Inflammation, which is induced by the immune response, is recognized as the driving factor in many diseases, including infections and inflammatory diseases, metabolic disorders and cancers. Genetic variations in pivotal genes associated with the immune response, particularly single nucleotide polymorphisms (SNPs), may account for predisposition and clinical outcome of diseases. Lipopolysaccharide (LPS)-binding protein (LBP) functions as an enhancer of the host response to LPS, the main component of the outer membrane of gram-native bacteria. Given the crucial role of LBP in inflammation, we will review the impact of SNPs in the LBP gene on infections and inflammatory diseases, metabolic disorders and cancers.
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spelling pubmed-82901852021-07-21 Effects of Lipopolysaccharide-Binding Protein (LBP) Single Nucleotide Polymorphism (SNP) in Infections, Inflammatory Diseases, Metabolic Disorders and Cancers Meng, Leilei Song, Zichen Liu, Anding Dahmen, Uta Yang, Xiao Fang, Haoshu Front Immunol Immunology Inflammation, which is induced by the immune response, is recognized as the driving factor in many diseases, including infections and inflammatory diseases, metabolic disorders and cancers. Genetic variations in pivotal genes associated with the immune response, particularly single nucleotide polymorphisms (SNPs), may account for predisposition and clinical outcome of diseases. Lipopolysaccharide (LPS)-binding protein (LBP) functions as an enhancer of the host response to LPS, the main component of the outer membrane of gram-native bacteria. Given the crucial role of LBP in inflammation, we will review the impact of SNPs in the LBP gene on infections and inflammatory diseases, metabolic disorders and cancers. Frontiers Media S.A. 2021-07-06 /pmc/articles/PMC8290185/ /pubmed/34295331 http://dx.doi.org/10.3389/fimmu.2021.681810 Text en Copyright © 2021 Meng, Song, Liu, Dahmen, Yang and Fang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Meng, Leilei
Song, Zichen
Liu, Anding
Dahmen, Uta
Yang, Xiao
Fang, Haoshu
Effects of Lipopolysaccharide-Binding Protein (LBP) Single Nucleotide Polymorphism (SNP) in Infections, Inflammatory Diseases, Metabolic Disorders and Cancers
title Effects of Lipopolysaccharide-Binding Protein (LBP) Single Nucleotide Polymorphism (SNP) in Infections, Inflammatory Diseases, Metabolic Disorders and Cancers
title_full Effects of Lipopolysaccharide-Binding Protein (LBP) Single Nucleotide Polymorphism (SNP) in Infections, Inflammatory Diseases, Metabolic Disorders and Cancers
title_fullStr Effects of Lipopolysaccharide-Binding Protein (LBP) Single Nucleotide Polymorphism (SNP) in Infections, Inflammatory Diseases, Metabolic Disorders and Cancers
title_full_unstemmed Effects of Lipopolysaccharide-Binding Protein (LBP) Single Nucleotide Polymorphism (SNP) in Infections, Inflammatory Diseases, Metabolic Disorders and Cancers
title_short Effects of Lipopolysaccharide-Binding Protein (LBP) Single Nucleotide Polymorphism (SNP) in Infections, Inflammatory Diseases, Metabolic Disorders and Cancers
title_sort effects of lipopolysaccharide-binding protein (lbp) single nucleotide polymorphism (snp) in infections, inflammatory diseases, metabolic disorders and cancers
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8290185/
https://www.ncbi.nlm.nih.gov/pubmed/34295331
http://dx.doi.org/10.3389/fimmu.2021.681810
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