The green tea catechin epigallocatechin gallate inhibits SARS-CoV-2 infection

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection has caused a pandemic with tens of millions of cases and more than a million deaths. The infection causes COVID-19, a disease of the respiratory system of divergent severity. No treatment exists. Epigallocatechin-3-gallate (E...

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Autores principales: Henss, Lisa, Auste, Arne, Schürmann, Christoph, Schmidt, Christin, von Rhein, Christine, Mühlebach, Michael D., Schnierle, Barbara S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Microbiology Society 2021
Materias:
Animal
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8290267/
https://www.ncbi.nlm.nih.gov/pubmed/33830908
http://dx.doi.org/10.1099/jgv.0.001574
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author Henss, Lisa
Auste, Arne
Schürmann, Christoph
Schmidt, Christin
von Rhein, Christine
Mühlebach, Michael D.
Schnierle, Barbara S.
author_facet Henss, Lisa
Auste, Arne
Schürmann, Christoph
Schmidt, Christin
von Rhein, Christine
Mühlebach, Michael D.
Schnierle, Barbara S.
author_sort Henss, Lisa
collection PubMed
description The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection has caused a pandemic with tens of millions of cases and more than a million deaths. The infection causes COVID-19, a disease of the respiratory system of divergent severity. No treatment exists. Epigallocatechin-3-gallate (EGCG), the major component of green tea, has several beneficial properties, including antiviral activities. Therefore, we examined whether EGCG has antiviral activity against SARS-CoV-2. EGCG blocked not only the entry of SARS-CoV-2, but also MERS- and SARS-CoV pseudotyped lentiviral vectors and inhibited virus infections in vitro. Mechanistically, inhibition of the SARS-CoV-2 spike–receptor interaction was observed. Thus, EGCG might be suitable for use as a lead structure to develop more effective anti-COVID-19 drugs.
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spelling pubmed-82902672021-07-20 The green tea catechin epigallocatechin gallate inhibits SARS-CoV-2 infection Henss, Lisa Auste, Arne Schürmann, Christoph Schmidt, Christin von Rhein, Christine Mühlebach, Michael D. Schnierle, Barbara S. J Gen Virol Animal The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection has caused a pandemic with tens of millions of cases and more than a million deaths. The infection causes COVID-19, a disease of the respiratory system of divergent severity. No treatment exists. Epigallocatechin-3-gallate (EGCG), the major component of green tea, has several beneficial properties, including antiviral activities. Therefore, we examined whether EGCG has antiviral activity against SARS-CoV-2. EGCG blocked not only the entry of SARS-CoV-2, but also MERS- and SARS-CoV pseudotyped lentiviral vectors and inhibited virus infections in vitro. Mechanistically, inhibition of the SARS-CoV-2 spike–receptor interaction was observed. Thus, EGCG might be suitable for use as a lead structure to develop more effective anti-COVID-19 drugs. Microbiology Society 2021-04-08 /pmc/articles/PMC8290267/ /pubmed/33830908 http://dx.doi.org/10.1099/jgv.0.001574 Text en © 2021 The Authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License. The Microbiology Society waived the open access fees for this article.
spellingShingle Animal
Henss, Lisa
Auste, Arne
Schürmann, Christoph
Schmidt, Christin
von Rhein, Christine
Mühlebach, Michael D.
Schnierle, Barbara S.
The green tea catechin epigallocatechin gallate inhibits SARS-CoV-2 infection
title The green tea catechin epigallocatechin gallate inhibits SARS-CoV-2 infection
title_full The green tea catechin epigallocatechin gallate inhibits SARS-CoV-2 infection
title_fullStr The green tea catechin epigallocatechin gallate inhibits SARS-CoV-2 infection
title_full_unstemmed The green tea catechin epigallocatechin gallate inhibits SARS-CoV-2 infection
title_short The green tea catechin epigallocatechin gallate inhibits SARS-CoV-2 infection
title_sort green tea catechin epigallocatechin gallate inhibits sars-cov-2 infection
topic Animal
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8290267/
https://www.ncbi.nlm.nih.gov/pubmed/33830908
http://dx.doi.org/10.1099/jgv.0.001574
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