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Enhanced Antitumor Response to Immune Checkpoint Blockade Exerted by Cisplatin-Induced Mutagenesis in a Murine Melanoma Model

Sequencing data from different types of cancers including melanomas demonstrate that tumors with high mutational loads are more likely to respond to immune checkpoint blockade (ICB) therapies. We have previously shown that low-dose intratumoral injection of the chemotherapeutic DNA damaging drug cis...

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Detalles Bibliográficos
Autores principales:	Gorgun, Falih M., Widen, Steven G., Tyler, Douglas S., Englander, Ella W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8290318/ https://www.ncbi.nlm.nih.gov/pubmed/34295826 http://dx.doi.org/10.3389/fonc.2021.701968

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