Cargando…
Altered Effective Connectivity of Children and Young Adults With Unilateral Amblyopia: A Resting-State Functional Magnetic Resonance Imaging Study
The altered functional connectivity (FC) in amblyopia has been investigated by many studies, but the specific causality of brain connectivity needs to be explored further to understand the brain activity of amblyopia. We investigated whether the effective connectivity (EC) of children and young adul...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8290343/ https://www.ncbi.nlm.nih.gov/pubmed/34295218 http://dx.doi.org/10.3389/fnins.2021.657576 |
_version_ | 1783724473241829376 |
---|---|
author | Dai, Peishan Zhou, Xiaoyan Ou, Yilin Xiong, Tong Zhang, Jinlong Chen, Zailiang Zou, Beiji Wei, Xin Wu, Ying Xiao, Manyi |
author_facet | Dai, Peishan Zhou, Xiaoyan Ou, Yilin Xiong, Tong Zhang, Jinlong Chen, Zailiang Zou, Beiji Wei, Xin Wu, Ying Xiao, Manyi |
author_sort | Dai, Peishan |
collection | PubMed |
description | The altered functional connectivity (FC) in amblyopia has been investigated by many studies, but the specific causality of brain connectivity needs to be explored further to understand the brain activity of amblyopia. We investigated whether the effective connectivity (EC) of children and young adults with amblyopia was altered. The subjects included 16 children and young adults with left eye amblyopia and 17 healthy controls (HCs). The abnormalities between the left/right primary visual cortex (PVC) and the other brain regions were investigated in a voxel-wise manner using the Granger causality analysis (GCA). According to the EC results in the HCs and the distribution of visual pathways, 12 regions of interest (ROIs) were selected to construct an EC network. The alteration of the EC network of the children and young adults with amblyopia was analyzed. In the voxel-wise manner analysis, amblyopia showed significantly decreased EC between the left/right of the PVC and the left middle frontal gyrus/left inferior frontal gyrus compared with the HCs. In the EC network analysis, compared with the HCs, amblyopia showed significantly decreased EC from the left calcarine fissure, posterior cingulate gyrus, left lingual gyrus, right lingual gyrus, and right fusiform gyrus to the right calcarine fissure. Amblyopia also showed significantly decreased EC from the right inferior frontal gyrus and right lingual gyrus to the left superior temporal gyrus compared with the HCs in the EC network analysis. The results may indicate that amblyopia altered the visual feedforward and feedback pathway, and amblyopia may have a greater relevance with the feedback pathway than the feedforward pathway. Amblyopia may also correlate with the feedforward of the third visual pathway. |
format | Online Article Text |
id | pubmed-8290343 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82903432021-07-21 Altered Effective Connectivity of Children and Young Adults With Unilateral Amblyopia: A Resting-State Functional Magnetic Resonance Imaging Study Dai, Peishan Zhou, Xiaoyan Ou, Yilin Xiong, Tong Zhang, Jinlong Chen, Zailiang Zou, Beiji Wei, Xin Wu, Ying Xiao, Manyi Front Neurosci Neuroscience The altered functional connectivity (FC) in amblyopia has been investigated by many studies, but the specific causality of brain connectivity needs to be explored further to understand the brain activity of amblyopia. We investigated whether the effective connectivity (EC) of children and young adults with amblyopia was altered. The subjects included 16 children and young adults with left eye amblyopia and 17 healthy controls (HCs). The abnormalities between the left/right primary visual cortex (PVC) and the other brain regions were investigated in a voxel-wise manner using the Granger causality analysis (GCA). According to the EC results in the HCs and the distribution of visual pathways, 12 regions of interest (ROIs) were selected to construct an EC network. The alteration of the EC network of the children and young adults with amblyopia was analyzed. In the voxel-wise manner analysis, amblyopia showed significantly decreased EC between the left/right of the PVC and the left middle frontal gyrus/left inferior frontal gyrus compared with the HCs. In the EC network analysis, compared with the HCs, amblyopia showed significantly decreased EC from the left calcarine fissure, posterior cingulate gyrus, left lingual gyrus, right lingual gyrus, and right fusiform gyrus to the right calcarine fissure. Amblyopia also showed significantly decreased EC from the right inferior frontal gyrus and right lingual gyrus to the left superior temporal gyrus compared with the HCs in the EC network analysis. The results may indicate that amblyopia altered the visual feedforward and feedback pathway, and amblyopia may have a greater relevance with the feedback pathway than the feedforward pathway. Amblyopia may also correlate with the feedforward of the third visual pathway. Frontiers Media S.A. 2021-07-06 /pmc/articles/PMC8290343/ /pubmed/34295218 http://dx.doi.org/10.3389/fnins.2021.657576 Text en Copyright © 2021 Dai, Zhou, Ou, Xiong, Zhang, Chen, Zou, Wei, Wu and Xiao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Dai, Peishan Zhou, Xiaoyan Ou, Yilin Xiong, Tong Zhang, Jinlong Chen, Zailiang Zou, Beiji Wei, Xin Wu, Ying Xiao, Manyi Altered Effective Connectivity of Children and Young Adults With Unilateral Amblyopia: A Resting-State Functional Magnetic Resonance Imaging Study |
title | Altered Effective Connectivity of Children and Young Adults With Unilateral Amblyopia: A Resting-State Functional Magnetic Resonance Imaging Study |
title_full | Altered Effective Connectivity of Children and Young Adults With Unilateral Amblyopia: A Resting-State Functional Magnetic Resonance Imaging Study |
title_fullStr | Altered Effective Connectivity of Children and Young Adults With Unilateral Amblyopia: A Resting-State Functional Magnetic Resonance Imaging Study |
title_full_unstemmed | Altered Effective Connectivity of Children and Young Adults With Unilateral Amblyopia: A Resting-State Functional Magnetic Resonance Imaging Study |
title_short | Altered Effective Connectivity of Children and Young Adults With Unilateral Amblyopia: A Resting-State Functional Magnetic Resonance Imaging Study |
title_sort | altered effective connectivity of children and young adults with unilateral amblyopia: a resting-state functional magnetic resonance imaging study |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8290343/ https://www.ncbi.nlm.nih.gov/pubmed/34295218 http://dx.doi.org/10.3389/fnins.2021.657576 |
work_keys_str_mv | AT daipeishan alteredeffectiveconnectivityofchildrenandyoungadultswithunilateralamblyopiaarestingstatefunctionalmagneticresonanceimagingstudy AT zhouxiaoyan alteredeffectiveconnectivityofchildrenandyoungadultswithunilateralamblyopiaarestingstatefunctionalmagneticresonanceimagingstudy AT ouyilin alteredeffectiveconnectivityofchildrenandyoungadultswithunilateralamblyopiaarestingstatefunctionalmagneticresonanceimagingstudy AT xiongtong alteredeffectiveconnectivityofchildrenandyoungadultswithunilateralamblyopiaarestingstatefunctionalmagneticresonanceimagingstudy AT zhangjinlong alteredeffectiveconnectivityofchildrenandyoungadultswithunilateralamblyopiaarestingstatefunctionalmagneticresonanceimagingstudy AT chenzailiang alteredeffectiveconnectivityofchildrenandyoungadultswithunilateralamblyopiaarestingstatefunctionalmagneticresonanceimagingstudy AT zoubeiji alteredeffectiveconnectivityofchildrenandyoungadultswithunilateralamblyopiaarestingstatefunctionalmagneticresonanceimagingstudy AT weixin alteredeffectiveconnectivityofchildrenandyoungadultswithunilateralamblyopiaarestingstatefunctionalmagneticresonanceimagingstudy AT wuying alteredeffectiveconnectivityofchildrenandyoungadultswithunilateralamblyopiaarestingstatefunctionalmagneticresonanceimagingstudy AT xiaomanyi alteredeffectiveconnectivityofchildrenandyoungadultswithunilateralamblyopiaarestingstatefunctionalmagneticresonanceimagingstudy |