Research Progress on the Antiviral Activity of Glycyrrhizin and its Derivatives in Liquorice

Liquorice is a traditional medicine. Triterpenoids such as glycyrrhizin and glycyrrhetinic acid are the main active constituents of liquorice. Studies have revealed that these compounds exert inhibitory effects on several viruses, including SARS-CoV-2. The main mechanisms of action of these compound...

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Autores principales: Huan, Changchao, Xu, Yao, Zhang, Wei, Guo, Tingting, Pan, Haochun, Gao, Song
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8290359/
https://www.ncbi.nlm.nih.gov/pubmed/34295250
http://dx.doi.org/10.3389/fphar.2021.680674
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author Huan, Changchao
Xu, Yao
Zhang, Wei
Guo, Tingting
Pan, Haochun
Gao, Song
author_facet Huan, Changchao
Xu, Yao
Zhang, Wei
Guo, Tingting
Pan, Haochun
Gao, Song
author_sort Huan, Changchao
collection PubMed
description Liquorice is a traditional medicine. Triterpenoids such as glycyrrhizin and glycyrrhetinic acid are the main active constituents of liquorice. Studies have revealed that these compounds exert inhibitory effects on several viruses, including SARS-CoV-2. The main mechanisms of action of these compounds include inhibition of virus replication, direct inactivation of viruses, inhibition of inflammation mediated by HMGB1/TLR4, inhibition of β-chemokines, reduction in the binding of HMGB1 to DNA to weaken the activity of viruses, and inhibition of reactive oxygen species formation. We herein review the research progress on the antiviral effects of glycyrrhizin and its derivatives. In addition, we emphasise the significance of exploring unknown antiviral mechanisms, structural modifications, and drug combinations in future studies.
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spelling pubmed-82903592021-07-21 Research Progress on the Antiviral Activity of Glycyrrhizin and its Derivatives in Liquorice Huan, Changchao Xu, Yao Zhang, Wei Guo, Tingting Pan, Haochun Gao, Song Front Pharmacol Pharmacology Liquorice is a traditional medicine. Triterpenoids such as glycyrrhizin and glycyrrhetinic acid are the main active constituents of liquorice. Studies have revealed that these compounds exert inhibitory effects on several viruses, including SARS-CoV-2. The main mechanisms of action of these compounds include inhibition of virus replication, direct inactivation of viruses, inhibition of inflammation mediated by HMGB1/TLR4, inhibition of β-chemokines, reduction in the binding of HMGB1 to DNA to weaken the activity of viruses, and inhibition of reactive oxygen species formation. We herein review the research progress on the antiviral effects of glycyrrhizin and its derivatives. In addition, we emphasise the significance of exploring unknown antiviral mechanisms, structural modifications, and drug combinations in future studies. Frontiers Media S.A. 2021-07-06 /pmc/articles/PMC8290359/ /pubmed/34295250 http://dx.doi.org/10.3389/fphar.2021.680674 Text en Copyright © 2021 Huan, Xu, Zhang, Guo, Pan and Gao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Huan, Changchao
Xu, Yao
Zhang, Wei
Guo, Tingting
Pan, Haochun
Gao, Song
Research Progress on the Antiviral Activity of Glycyrrhizin and its Derivatives in Liquorice
title Research Progress on the Antiviral Activity of Glycyrrhizin and its Derivatives in Liquorice
title_full Research Progress on the Antiviral Activity of Glycyrrhizin and its Derivatives in Liquorice
title_fullStr Research Progress on the Antiviral Activity of Glycyrrhizin and its Derivatives in Liquorice
title_full_unstemmed Research Progress on the Antiviral Activity of Glycyrrhizin and its Derivatives in Liquorice
title_short Research Progress on the Antiviral Activity of Glycyrrhizin and its Derivatives in Liquorice
title_sort research progress on the antiviral activity of glycyrrhizin and its derivatives in liquorice
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8290359/
https://www.ncbi.nlm.nih.gov/pubmed/34295250
http://dx.doi.org/10.3389/fphar.2021.680674
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