SARS-CoV-2 vaccination in the context of original antigenic sin

Immunological memory is the ability of the adaptive immune system to ensure a persistent protective effect after immunization. However, it can also be a limitation to building a sufficient level of protective antibodies specific to new mutations of the virus. It is imperative to bear this phenomenon...

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Detalles Bibliográficos
Autores principales: Petráš, Marek, Králová Lesná, Ivana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Coronavirus – Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8290366/
https://www.ncbi.nlm.nih.gov/pubmed/34242123
http://dx.doi.org/10.1080/21645515.2021.1949953
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author Petráš, Marek
Králová Lesná, Ivana
author_facet Petráš, Marek
Králová Lesná, Ivana
author_sort Petráš, Marek
collection PubMed
description Immunological memory is the ability of the adaptive immune system to ensure a persistent protective effect after immunization. However, it can also be a limitation to building a sufficient level of protective antibodies specific to new mutations of the virus. It is imperative to bear this phenomenon (called “original antigenic sin”) in mind and make every effort to overcome its inherent pitfalls when updating current and designing new vaccines.
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spelling pubmed-82903662021-07-21 SARS-CoV-2 vaccination in the context of original antigenic sin Petráš, Marek Králová Lesná, Ivana Hum Vaccin Immunother Coronavirus – Commentary Immunological memory is the ability of the adaptive immune system to ensure a persistent protective effect after immunization. However, it can also be a limitation to building a sufficient level of protective antibodies specific to new mutations of the virus. It is imperative to bear this phenomenon (called “original antigenic sin”) in mind and make every effort to overcome its inherent pitfalls when updating current and designing new vaccines. Taylor & Francis 2021-07-09 /pmc/articles/PMC8290366/ /pubmed/34242123 http://dx.doi.org/10.1080/21645515.2021.1949953 Text en © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Coronavirus – Commentary
Petráš, Marek
Králová Lesná, Ivana
SARS-CoV-2 vaccination in the context of original antigenic sin
title SARS-CoV-2 vaccination in the context of original antigenic sin
title_full SARS-CoV-2 vaccination in the context of original antigenic sin
title_fullStr SARS-CoV-2 vaccination in the context of original antigenic sin
title_full_unstemmed SARS-CoV-2 vaccination in the context of original antigenic sin
title_short SARS-CoV-2 vaccination in the context of original antigenic sin
title_sort sars-cov-2 vaccination in the context of original antigenic sin
topic Coronavirus – Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8290366/
https://www.ncbi.nlm.nih.gov/pubmed/34242123
http://dx.doi.org/10.1080/21645515.2021.1949953
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