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Clinicopathological features of gastric inflammatory myofibroblastic tumor: Report of five cases
The present study reported on the histomorphological observations and immunohistochemical features of five cases of gastric inflammatory myofibroblastic tumor (IMT). Loosely arranged fat fusiform myofibroblast-fibroblasts and diffusely or patchily distributed inflammatory cells, which formed a diver...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8290396/ https://www.ncbi.nlm.nih.gov/pubmed/34335890 http://dx.doi.org/10.3892/etm.2021.10380 |
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author | Wang, Yangkun Shen, Lan Yun, Tian Zhu, Chaoya Wang, Ping Wang, Sunan |
author_facet | Wang, Yangkun Shen, Lan Yun, Tian Zhu, Chaoya Wang, Ping Wang, Sunan |
author_sort | Wang, Yangkun |
collection | PubMed |
description | The present study reported on the histomorphological observations and immunohistochemical features of five cases of gastric inflammatory myofibroblastic tumor (IMT). Loosely arranged fat fusiform myofibroblast-fibroblasts and diffusely or patchily distributed inflammatory cells, which formed a diverse morphological structure, were observed. In the mucous vascular structure, mucoid or collagenous areas, fibromatosis- or scar-like lesions were generally <10 mm in size and both had diffuse or patchy plasma cells, lymphocytes and other inflammatory-cell infiltration backgrounds. The immunophenotype was vimentin- and smooth muscle actin-positive with pan-cytokeratin, desmin and calponin expression and CD34-positive foci; furthermore, three cases were positive for anaplastic lymphoma kinase expression. Gastric IMT is rare, with unique histopathological changes and corrosion-like invasion of the smooth muscle of the stomach wall, blood vessels, nerves and adipose tissue. It should be differentiated from a variety of spindle cell tumor types and tumor-like lesions. |
format | Online Article Text |
id | pubmed-8290396 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-82903962021-07-30 Clinicopathological features of gastric inflammatory myofibroblastic tumor: Report of five cases Wang, Yangkun Shen, Lan Yun, Tian Zhu, Chaoya Wang, Ping Wang, Sunan Exp Ther Med Articles The present study reported on the histomorphological observations and immunohistochemical features of five cases of gastric inflammatory myofibroblastic tumor (IMT). Loosely arranged fat fusiform myofibroblast-fibroblasts and diffusely or patchily distributed inflammatory cells, which formed a diverse morphological structure, were observed. In the mucous vascular structure, mucoid or collagenous areas, fibromatosis- or scar-like lesions were generally <10 mm in size and both had diffuse or patchy plasma cells, lymphocytes and other inflammatory-cell infiltration backgrounds. The immunophenotype was vimentin- and smooth muscle actin-positive with pan-cytokeratin, desmin and calponin expression and CD34-positive foci; furthermore, three cases were positive for anaplastic lymphoma kinase expression. Gastric IMT is rare, with unique histopathological changes and corrosion-like invasion of the smooth muscle of the stomach wall, blood vessels, nerves and adipose tissue. It should be differentiated from a variety of spindle cell tumor types and tumor-like lesions. D.A. Spandidos 2021-09 2021-07-01 /pmc/articles/PMC8290396/ /pubmed/34335890 http://dx.doi.org/10.3892/etm.2021.10380 Text en Copyright: © Wang et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Wang, Yangkun Shen, Lan Yun, Tian Zhu, Chaoya Wang, Ping Wang, Sunan Clinicopathological features of gastric inflammatory myofibroblastic tumor: Report of five cases |
title | Clinicopathological features of gastric inflammatory myofibroblastic tumor: Report of five cases |
title_full | Clinicopathological features of gastric inflammatory myofibroblastic tumor: Report of five cases |
title_fullStr | Clinicopathological features of gastric inflammatory myofibroblastic tumor: Report of five cases |
title_full_unstemmed | Clinicopathological features of gastric inflammatory myofibroblastic tumor: Report of five cases |
title_short | Clinicopathological features of gastric inflammatory myofibroblastic tumor: Report of five cases |
title_sort | clinicopathological features of gastric inflammatory myofibroblastic tumor: report of five cases |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8290396/ https://www.ncbi.nlm.nih.gov/pubmed/34335890 http://dx.doi.org/10.3892/etm.2021.10380 |
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