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The Effects of Receptor Activator of NF-κB Ligand-Binding Peptides on Bone Resorption and Bone Formation

Receptor activator of NF-κB ligand (RANKL)-binding peptides inhibit bone resorption and were recently shown to activate bone formation. The stimulatory mechanism underlying bone formation associated with these peptides was explained as RANKL-reverse signaling, wherein RANKL molecules on osteoblasts...

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Autores principales: Rashed, Fatma, Kamijyo, Shingo, Shimizu, Yuri, Hirohashi, Yuna, Khan, Masud, Sugamori, Yasutaka, Murali, Ramachandran, Aoki, Kazuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8290838/
https://www.ncbi.nlm.nih.gov/pubmed/34295889
http://dx.doi.org/10.3389/fcell.2021.648084
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author Rashed, Fatma
Kamijyo, Shingo
Shimizu, Yuri
Hirohashi, Yuna
Khan, Masud
Sugamori, Yasutaka
Murali, Ramachandran
Aoki, Kazuhiro
author_facet Rashed, Fatma
Kamijyo, Shingo
Shimizu, Yuri
Hirohashi, Yuna
Khan, Masud
Sugamori, Yasutaka
Murali, Ramachandran
Aoki, Kazuhiro
author_sort Rashed, Fatma
collection PubMed
description Receptor activator of NF-κB ligand (RANKL)-binding peptides inhibit bone resorption and were recently shown to activate bone formation. The stimulatory mechanism underlying bone formation associated with these peptides was explained as RANKL-reverse signaling, wherein RANKL molecules on osteoblasts work as receptors to stimulate osteoblast differentiation. However, why RANKL-binding peptides stimulate osteoblast differentiation while osteoprotegerin (OPG), which is well known to bind to RANKL, cannot activate osteoblast differentiation has remained unclear. In this mini-review, we introduce three main issues: (1) The inhibitory effects of two RANKL-binding peptides (W9 and OP3-4) on bone resorption; (2) The stimulatory effects of the RANKL-binding peptides on osteoblast differentiation; and (3) The accumulation and membrane clustering of RANKL molecules at the cell surface of osteoblasts as a potential molecular switch stimulating osteoblast differentiation by RANKL-binding peptides.
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spelling pubmed-82908382021-07-21 The Effects of Receptor Activator of NF-κB Ligand-Binding Peptides on Bone Resorption and Bone Formation Rashed, Fatma Kamijyo, Shingo Shimizu, Yuri Hirohashi, Yuna Khan, Masud Sugamori, Yasutaka Murali, Ramachandran Aoki, Kazuhiro Front Cell Dev Biol Cell and Developmental Biology Receptor activator of NF-κB ligand (RANKL)-binding peptides inhibit bone resorption and were recently shown to activate bone formation. The stimulatory mechanism underlying bone formation associated with these peptides was explained as RANKL-reverse signaling, wherein RANKL molecules on osteoblasts work as receptors to stimulate osteoblast differentiation. However, why RANKL-binding peptides stimulate osteoblast differentiation while osteoprotegerin (OPG), which is well known to bind to RANKL, cannot activate osteoblast differentiation has remained unclear. In this mini-review, we introduce three main issues: (1) The inhibitory effects of two RANKL-binding peptides (W9 and OP3-4) on bone resorption; (2) The stimulatory effects of the RANKL-binding peptides on osteoblast differentiation; and (3) The accumulation and membrane clustering of RANKL molecules at the cell surface of osteoblasts as a potential molecular switch stimulating osteoblast differentiation by RANKL-binding peptides. Frontiers Media S.A. 2021-07-06 /pmc/articles/PMC8290838/ /pubmed/34295889 http://dx.doi.org/10.3389/fcell.2021.648084 Text en Copyright © 2021 Rashed, Kamijyo, Shimizu, Hirohashi, Khan, Sugamori, Murali and Aoki. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Rashed, Fatma
Kamijyo, Shingo
Shimizu, Yuri
Hirohashi, Yuna
Khan, Masud
Sugamori, Yasutaka
Murali, Ramachandran
Aoki, Kazuhiro
The Effects of Receptor Activator of NF-κB Ligand-Binding Peptides on Bone Resorption and Bone Formation
title The Effects of Receptor Activator of NF-κB Ligand-Binding Peptides on Bone Resorption and Bone Formation
title_full The Effects of Receptor Activator of NF-κB Ligand-Binding Peptides on Bone Resorption and Bone Formation
title_fullStr The Effects of Receptor Activator of NF-κB Ligand-Binding Peptides on Bone Resorption and Bone Formation
title_full_unstemmed The Effects of Receptor Activator of NF-κB Ligand-Binding Peptides on Bone Resorption and Bone Formation
title_short The Effects of Receptor Activator of NF-κB Ligand-Binding Peptides on Bone Resorption and Bone Formation
title_sort effects of receptor activator of nf-κb ligand-binding peptides on bone resorption and bone formation
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8290838/
https://www.ncbi.nlm.nih.gov/pubmed/34295889
http://dx.doi.org/10.3389/fcell.2021.648084
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