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Lipid–oligonucleotide conjugates for bioapplications
Lipid–oligonucleotide conjugates (LONs) are powerful molecular-engineering materials for various applications ranging from biosensors to biomedicine. Their unique amphiphilic structures enable the self-assembly and the conveyance of information with high fidelity. In particular, LONs present remarka...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8290939/ https://www.ncbi.nlm.nih.gov/pubmed/34691533 http://dx.doi.org/10.1093/nsr/nwaa161 |
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author | Li, Xiaowei Feng, Kejun Li, Long Yang, Lu Pan, Xiaoshu Yazd, Hoda Safari Cui, Cheng Li, Juan Moroz, Leonid Sun, Yujia Wang, Bang Li, Xiang Huang, Tong Tan, Weihong |
author_facet | Li, Xiaowei Feng, Kejun Li, Long Yang, Lu Pan, Xiaoshu Yazd, Hoda Safari Cui, Cheng Li, Juan Moroz, Leonid Sun, Yujia Wang, Bang Li, Xiang Huang, Tong Tan, Weihong |
author_sort | Li, Xiaowei |
collection | PubMed |
description | Lipid–oligonucleotide conjugates (LONs) are powerful molecular-engineering materials for various applications ranging from biosensors to biomedicine. Their unique amphiphilic structures enable the self-assembly and the conveyance of information with high fidelity. In particular, LONs present remarkable potential in measuring cellular mechanical forces and monitoring cell behaviors. LONs are also essential sensing tools for intracellular imaging and have been employed in developing cell-surface-anchored DNA nanostructures for biomimetic-engineering studies. When incorporating therapeutic oligonucleotides or small-molecule drugs, LONs hold promise for targeted therapy. Moreover, LONs mediate the controllable assembly and fusion of vesicles based on DNA-strand displacements, contributing to nanoreactor construction and macromolecule delivery. In this review, we will summarize the general synthesis strategies of LONs, provide some characterization analysis and emphasize recent advances in bioanalytical and biomedical applications. We will also consider the relevant challenges and suggest future directions for building better functional LONs in nanotechnology and materials-science applications. |
format | Online Article Text |
id | pubmed-8290939 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-82909392021-10-21 Lipid–oligonucleotide conjugates for bioapplications Li, Xiaowei Feng, Kejun Li, Long Yang, Lu Pan, Xiaoshu Yazd, Hoda Safari Cui, Cheng Li, Juan Moroz, Leonid Sun, Yujia Wang, Bang Li, Xiang Huang, Tong Tan, Weihong Natl Sci Rev Chemistry Lipid–oligonucleotide conjugates (LONs) are powerful molecular-engineering materials for various applications ranging from biosensors to biomedicine. Their unique amphiphilic structures enable the self-assembly and the conveyance of information with high fidelity. In particular, LONs present remarkable potential in measuring cellular mechanical forces and monitoring cell behaviors. LONs are also essential sensing tools for intracellular imaging and have been employed in developing cell-surface-anchored DNA nanostructures for biomimetic-engineering studies. When incorporating therapeutic oligonucleotides or small-molecule drugs, LONs hold promise for targeted therapy. Moreover, LONs mediate the controllable assembly and fusion of vesicles based on DNA-strand displacements, contributing to nanoreactor construction and macromolecule delivery. In this review, we will summarize the general synthesis strategies of LONs, provide some characterization analysis and emphasize recent advances in bioanalytical and biomedical applications. We will also consider the relevant challenges and suggest future directions for building better functional LONs in nanotechnology and materials-science applications. Oxford University Press 2020-07-09 /pmc/articles/PMC8290939/ /pubmed/34691533 http://dx.doi.org/10.1093/nsr/nwaa161 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of China Science Publishing & Media Ltd. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Chemistry Li, Xiaowei Feng, Kejun Li, Long Yang, Lu Pan, Xiaoshu Yazd, Hoda Safari Cui, Cheng Li, Juan Moroz, Leonid Sun, Yujia Wang, Bang Li, Xiang Huang, Tong Tan, Weihong Lipid–oligonucleotide conjugates for bioapplications |
title | Lipid–oligonucleotide conjugates for bioapplications |
title_full | Lipid–oligonucleotide conjugates for bioapplications |
title_fullStr | Lipid–oligonucleotide conjugates for bioapplications |
title_full_unstemmed | Lipid–oligonucleotide conjugates for bioapplications |
title_short | Lipid–oligonucleotide conjugates for bioapplications |
title_sort | lipid–oligonucleotide conjugates for bioapplications |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8290939/ https://www.ncbi.nlm.nih.gov/pubmed/34691533 http://dx.doi.org/10.1093/nsr/nwaa161 |
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