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Gastric schwannoma treated by endoscopic full-thickness resection and endoscopic purse-string suture: A case report

BACKGROUND: Schwannomas, also known as neurinomas, are tumors that derive from Schwann cells. Gastrointestinal schwannomas are extremely rare, but the stomach is the most common site. Gastric schwannomas are usually asymptomatic. Endoscopy and imaging modalities might offer useful preliminary diagno...

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Autores principales: Lu, Zhi-Yu, Zhao, Dun-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291012/
https://www.ncbi.nlm.nih.gov/pubmed/34321856
http://dx.doi.org/10.3748/wjg.v27.i25.3940
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author Lu, Zhi-Yu
Zhao, Dun-Yong
author_facet Lu, Zhi-Yu
Zhao, Dun-Yong
author_sort Lu, Zhi-Yu
collection PubMed
description BACKGROUND: Schwannomas, also known as neurinomas, are tumors that derive from Schwann cells. Gastrointestinal schwannomas are extremely rare, but the stomach is the most common site. Gastric schwannomas are usually asymptomatic. Endoscopy and imaging modalities might offer useful preliminary diagnostic information. However, to diagnose schwannoma, the immunohistochemical positivity for S-100 protein is essential, whereas CD117, CD34, SMA, desmin, and DOG-1 are negative. CASE SUMMARY: A 45-year-old female was found to have a gastric mass during a medical examination, which was diagnosed as a gastric schwannoma. We performed endoscopic full-thickness resection and endoscopic purse-string suture. Pathology and immunohistochemical staining confirmed the diagnosis of gastric schwannoma through the positivity of S-100 protein. Furthermore, to exclude the misdiagnosis of gastrointestinal stromal tumor, we performed a mutational detection of the c-Kit and PDGFRA genes. Postoperative follow-up revealed that the patient recovered well. CONCLUSION: Immunohistochemical staining is essential for the diagnosis of schwannoma. Endoscopic full-thickness resection is an effective treatment method for gastric schwannoma.
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spelling pubmed-82910122021-07-27 Gastric schwannoma treated by endoscopic full-thickness resection and endoscopic purse-string suture: A case report Lu, Zhi-Yu Zhao, Dun-Yong World J Gastroenterol Case Report BACKGROUND: Schwannomas, also known as neurinomas, are tumors that derive from Schwann cells. Gastrointestinal schwannomas are extremely rare, but the stomach is the most common site. Gastric schwannomas are usually asymptomatic. Endoscopy and imaging modalities might offer useful preliminary diagnostic information. However, to diagnose schwannoma, the immunohistochemical positivity for S-100 protein is essential, whereas CD117, CD34, SMA, desmin, and DOG-1 are negative. CASE SUMMARY: A 45-year-old female was found to have a gastric mass during a medical examination, which was diagnosed as a gastric schwannoma. We performed endoscopic full-thickness resection and endoscopic purse-string suture. Pathology and immunohistochemical staining confirmed the diagnosis of gastric schwannoma through the positivity of S-100 protein. Furthermore, to exclude the misdiagnosis of gastrointestinal stromal tumor, we performed a mutational detection of the c-Kit and PDGFRA genes. Postoperative follow-up revealed that the patient recovered well. CONCLUSION: Immunohistochemical staining is essential for the diagnosis of schwannoma. Endoscopic full-thickness resection is an effective treatment method for gastric schwannoma. Baishideng Publishing Group Inc 2021-07-07 2021-07-07 /pmc/articles/PMC8291012/ /pubmed/34321856 http://dx.doi.org/10.3748/wjg.v27.i25.3940 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Case Report
Lu, Zhi-Yu
Zhao, Dun-Yong
Gastric schwannoma treated by endoscopic full-thickness resection and endoscopic purse-string suture: A case report
title Gastric schwannoma treated by endoscopic full-thickness resection and endoscopic purse-string suture: A case report
title_full Gastric schwannoma treated by endoscopic full-thickness resection and endoscopic purse-string suture: A case report
title_fullStr Gastric schwannoma treated by endoscopic full-thickness resection and endoscopic purse-string suture: A case report
title_full_unstemmed Gastric schwannoma treated by endoscopic full-thickness resection and endoscopic purse-string suture: A case report
title_short Gastric schwannoma treated by endoscopic full-thickness resection and endoscopic purse-string suture: A case report
title_sort gastric schwannoma treated by endoscopic full-thickness resection and endoscopic purse-string suture: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291012/
https://www.ncbi.nlm.nih.gov/pubmed/34321856
http://dx.doi.org/10.3748/wjg.v27.i25.3940
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