Human immune repertoire in hepatitis B virus infection

Hepatitis B virus (HBV) infection is a public health threat that affects 257 million people worldwide and can progress to liver cirrhosis, liver failure, and hepatocellular carcinoma. The HBV antigen- induced adaptive immune response plays an important role in HBV clearance. Immune repertoire sequen...

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Autores principales: Zhan, Qiao, Xu, Jing-Hang, Yu, Yan-Yan, Lo KK, Emily, El-Nezami, Hani, Zeng, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2021
Materias:
Minireviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291018/
https://www.ncbi.nlm.nih.gov/pubmed/34321844
http://dx.doi.org/10.3748/wjg.v27.i25.3790
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author Zhan, Qiao
Xu, Jing-Hang
Yu, Yan-Yan
Lo KK, Emily
El-Nezami, Hani
Zeng, Zheng
author_facet Zhan, Qiao
Xu, Jing-Hang
Yu, Yan-Yan
Lo KK, Emily
El-Nezami, Hani
Zeng, Zheng
author_sort Zhan, Qiao
collection PubMed
description Hepatitis B virus (HBV) infection is a public health threat that affects 257 million people worldwide and can progress to liver cirrhosis, liver failure, and hepatocellular carcinoma. The HBV antigen- induced adaptive immune response plays an important role in HBV clearance. Immune repertoire sequencing (IRS) has been used to investigate the molecular mechanisms behind the immune system, find novel ways to treat HBV infection, and evaluate the genetic responses and immune characteristics of individuals infected by HBV or immunized by HBV vaccine. This review summarizes the human immune repertoire analysis methodology, and the application of the IRS in the prediction of HBV infection progression, treatment, and vaccination.
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spelling pubmed-82910182021-07-27 Human immune repertoire in hepatitis B virus infection Zhan, Qiao Xu, Jing-Hang Yu, Yan-Yan Lo KK, Emily El-Nezami, Hani Zeng, Zheng World J Gastroenterol Minireviews Hepatitis B virus (HBV) infection is a public health threat that affects 257 million people worldwide and can progress to liver cirrhosis, liver failure, and hepatocellular carcinoma. The HBV antigen- induced adaptive immune response plays an important role in HBV clearance. Immune repertoire sequencing (IRS) has been used to investigate the molecular mechanisms behind the immune system, find novel ways to treat HBV infection, and evaluate the genetic responses and immune characteristics of individuals infected by HBV or immunized by HBV vaccine. This review summarizes the human immune repertoire analysis methodology, and the application of the IRS in the prediction of HBV infection progression, treatment, and vaccination. Baishideng Publishing Group Inc 2021-07-07 2021-07-07 /pmc/articles/PMC8291018/ /pubmed/34321844 http://dx.doi.org/10.3748/wjg.v27.i25.3790 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Minireviews
Zhan, Qiao
Xu, Jing-Hang
Yu, Yan-Yan
Lo KK, Emily
El-Nezami, Hani
Zeng, Zheng
Human immune repertoire in hepatitis B virus infection
title Human immune repertoire in hepatitis B virus infection
title_full Human immune repertoire in hepatitis B virus infection
title_fullStr Human immune repertoire in hepatitis B virus infection
title_full_unstemmed Human immune repertoire in hepatitis B virus infection
title_short Human immune repertoire in hepatitis B virus infection
title_sort human immune repertoire in hepatitis b virus infection
topic Minireviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291018/
https://www.ncbi.nlm.nih.gov/pubmed/34321844
http://dx.doi.org/10.3748/wjg.v27.i25.3790
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