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Physical and Biological Characteristics of Particle Therapy for Oncologists

Particle therapy is a promising and evolving modality of radiotherapy that can be used to treat tumors that are radioresistant to conventional photon beam radiotherapy. It has unique biological and physical advantages compared with conventional radiotherapy. The characteristic feature of particle th...

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Autores principales: Byun, Hwa Kyung, Han, Min Cheol, Yang, Kyungmi, Kim, Jin Sung, Yoo, Gyu Sang, Koom, Woong Sub, Kim, Yong Bae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Cancer Association 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291193/
https://www.ncbi.nlm.nih.gov/pubmed/34139805
http://dx.doi.org/10.4143/crt.2021.066
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author Byun, Hwa Kyung
Han, Min Cheol
Yang, Kyungmi
Kim, Jin Sung
Yoo, Gyu Sang
Koom, Woong Sub
Kim, Yong Bae
author_facet Byun, Hwa Kyung
Han, Min Cheol
Yang, Kyungmi
Kim, Jin Sung
Yoo, Gyu Sang
Koom, Woong Sub
Kim, Yong Bae
author_sort Byun, Hwa Kyung
collection PubMed
description Particle therapy is a promising and evolving modality of radiotherapy that can be used to treat tumors that are radioresistant to conventional photon beam radiotherapy. It has unique biological and physical advantages compared with conventional radiotherapy. The characteristic feature of particle therapy is the “Bragg peak,” a steep and localized peak of dose, that enables precise delivery of the radiation dose to the tumor while effectively sparing normal organs. Especially, the charged particles (e.g., proton, helium, carbon) cause a high rate of energy loss along the track, thereby leading to high biological effectiveness, which makes particle therapy attractive. Using this property, the particle beam induces more severe DNA double-strand breaks than the photon beam, which is less influenced by the oxygen level. This review describes the general biological and physical aspects of particle therapy for oncologists, including non-radiation oncologists and beginners in the field.
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spelling pubmed-82911932021-08-04 Physical and Biological Characteristics of Particle Therapy for Oncologists Byun, Hwa Kyung Han, Min Cheol Yang, Kyungmi Kim, Jin Sung Yoo, Gyu Sang Koom, Woong Sub Kim, Yong Bae Cancer Res Treat Special Article Particle therapy is a promising and evolving modality of radiotherapy that can be used to treat tumors that are radioresistant to conventional photon beam radiotherapy. It has unique biological and physical advantages compared with conventional radiotherapy. The characteristic feature of particle therapy is the “Bragg peak,” a steep and localized peak of dose, that enables precise delivery of the radiation dose to the tumor while effectively sparing normal organs. Especially, the charged particles (e.g., proton, helium, carbon) cause a high rate of energy loss along the track, thereby leading to high biological effectiveness, which makes particle therapy attractive. Using this property, the particle beam induces more severe DNA double-strand breaks than the photon beam, which is less influenced by the oxygen level. This review describes the general biological and physical aspects of particle therapy for oncologists, including non-radiation oncologists and beginners in the field. Korean Cancer Association 2021-07 2021-06-16 /pmc/articles/PMC8291193/ /pubmed/34139805 http://dx.doi.org/10.4143/crt.2021.066 Text en Copyright © 2021 by the Korean Cancer Association https://creativecommons.org/licenses/by-nc/4.0/This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Special Article
Byun, Hwa Kyung
Han, Min Cheol
Yang, Kyungmi
Kim, Jin Sung
Yoo, Gyu Sang
Koom, Woong Sub
Kim, Yong Bae
Physical and Biological Characteristics of Particle Therapy for Oncologists
title Physical and Biological Characteristics of Particle Therapy for Oncologists
title_full Physical and Biological Characteristics of Particle Therapy for Oncologists
title_fullStr Physical and Biological Characteristics of Particle Therapy for Oncologists
title_full_unstemmed Physical and Biological Characteristics of Particle Therapy for Oncologists
title_short Physical and Biological Characteristics of Particle Therapy for Oncologists
title_sort physical and biological characteristics of particle therapy for oncologists
topic Special Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291193/
https://www.ncbi.nlm.nih.gov/pubmed/34139805
http://dx.doi.org/10.4143/crt.2021.066
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