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Association among Body Mass Index, Genetic Variants of FTO, and Thyroid Cancer Risk: A Hospital-Based Case-Control Study of the Cancer Screenee Cohort in Korea

PURPOSE: Obesity has been determined to be associated with fat mass and obesity-associated (FTO) gene and thyroid cancer risk. However, the effect of combined interactions between obesity and the FTO gene on thyroid cancer needs further investigation. This study aimed to examine whether interactions...

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Autores principales: Hoang, Tung, Song, Dayoung, Lee, Jeonghee, Lee, Eun Kyung, Hwangbo, Yul, Kim, Jeongseon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Cancer Association 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291195/
https://www.ncbi.nlm.nih.gov/pubmed/33285050
http://dx.doi.org/10.4143/crt.2020.720
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author Hoang, Tung
Song, Dayoung
Lee, Jeonghee
Lee, Eun Kyung
Hwangbo, Yul
Kim, Jeongseon
author_facet Hoang, Tung
Song, Dayoung
Lee, Jeonghee
Lee, Eun Kyung
Hwangbo, Yul
Kim, Jeongseon
author_sort Hoang, Tung
collection PubMed
description PURPOSE: Obesity has been determined to be associated with fat mass and obesity-associated (FTO) gene and thyroid cancer risk. However, the effect of combined interactions between obesity and the FTO gene on thyroid cancer needs further investigation. This study aimed to examine whether interactions between body mass index (BMI) and the FTO gene are associated with an increased risk of thyroid cancer. MATERIALS AND METHODS: A total of 705 thyroid cancer cases and 705 sex- and age-matched normal controls were selected from the Cancer Screenee Cohort in National Cancer Center, Korea. A conditional logistic regression model was used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) for the measure of associations and the combined effect of BMI and FTO gene on thyroid cancer. RESULTS: BMI was associated with an increased risk of thyroid cancer in subclasses of overweight (23–24.9 kg/m(2); adjusted OR, 1.50; 95% CI, 1.12 to 2.00) and obese (≥ 25 kg/m(2)) (adjusted OR, 1.62; 95% CI, 1.23 to 2.14). There were positive associations between the FTO genetic variants rs8047395 and rs8044769 and an increased risk of thyroid cancer. Additionally, the combination of BMI subclasses and FTO gene variants was significantly associated with thyroid cancer risk in the codominant (rs17817288), dominant (rs9937053, rs12149832, rs1861867, and rs7195539), and recessive (rs17817288 and rs8044769) models. CONCLUSION: Findings from this study identified the effects of BMI on thyroid cancer risk among individuals carrying rs17817288, rs9937053, rs12149832, rs1861867, rs7195539, and rs8044769, whereas the effects of BMI may be modified according to individual characteristics of other FTO variants.
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spelling pubmed-82911952021-08-04 Association among Body Mass Index, Genetic Variants of FTO, and Thyroid Cancer Risk: A Hospital-Based Case-Control Study of the Cancer Screenee Cohort in Korea Hoang, Tung Song, Dayoung Lee, Jeonghee Lee, Eun Kyung Hwangbo, Yul Kim, Jeongseon Cancer Res Treat Original Article PURPOSE: Obesity has been determined to be associated with fat mass and obesity-associated (FTO) gene and thyroid cancer risk. However, the effect of combined interactions between obesity and the FTO gene on thyroid cancer needs further investigation. This study aimed to examine whether interactions between body mass index (BMI) and the FTO gene are associated with an increased risk of thyroid cancer. MATERIALS AND METHODS: A total of 705 thyroid cancer cases and 705 sex- and age-matched normal controls were selected from the Cancer Screenee Cohort in National Cancer Center, Korea. A conditional logistic regression model was used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) for the measure of associations and the combined effect of BMI and FTO gene on thyroid cancer. RESULTS: BMI was associated with an increased risk of thyroid cancer in subclasses of overweight (23–24.9 kg/m(2); adjusted OR, 1.50; 95% CI, 1.12 to 2.00) and obese (≥ 25 kg/m(2)) (adjusted OR, 1.62; 95% CI, 1.23 to 2.14). There were positive associations between the FTO genetic variants rs8047395 and rs8044769 and an increased risk of thyroid cancer. Additionally, the combination of BMI subclasses and FTO gene variants was significantly associated with thyroid cancer risk in the codominant (rs17817288), dominant (rs9937053, rs12149832, rs1861867, and rs7195539), and recessive (rs17817288 and rs8044769) models. CONCLUSION: Findings from this study identified the effects of BMI on thyroid cancer risk among individuals carrying rs17817288, rs9937053, rs12149832, rs1861867, rs7195539, and rs8044769, whereas the effects of BMI may be modified according to individual characteristics of other FTO variants. Korean Cancer Association 2021-07 2020-12-07 /pmc/articles/PMC8291195/ /pubmed/33285050 http://dx.doi.org/10.4143/crt.2020.720 Text en Copyright © 2021 by the Korean Cancer Association https://creativecommons.org/licenses/by-nc/4.0/This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Hoang, Tung
Song, Dayoung
Lee, Jeonghee
Lee, Eun Kyung
Hwangbo, Yul
Kim, Jeongseon
Association among Body Mass Index, Genetic Variants of FTO, and Thyroid Cancer Risk: A Hospital-Based Case-Control Study of the Cancer Screenee Cohort in Korea
title Association among Body Mass Index, Genetic Variants of FTO, and Thyroid Cancer Risk: A Hospital-Based Case-Control Study of the Cancer Screenee Cohort in Korea
title_full Association among Body Mass Index, Genetic Variants of FTO, and Thyroid Cancer Risk: A Hospital-Based Case-Control Study of the Cancer Screenee Cohort in Korea
title_fullStr Association among Body Mass Index, Genetic Variants of FTO, and Thyroid Cancer Risk: A Hospital-Based Case-Control Study of the Cancer Screenee Cohort in Korea
title_full_unstemmed Association among Body Mass Index, Genetic Variants of FTO, and Thyroid Cancer Risk: A Hospital-Based Case-Control Study of the Cancer Screenee Cohort in Korea
title_short Association among Body Mass Index, Genetic Variants of FTO, and Thyroid Cancer Risk: A Hospital-Based Case-Control Study of the Cancer Screenee Cohort in Korea
title_sort association among body mass index, genetic variants of fto, and thyroid cancer risk: a hospital-based case-control study of the cancer screenee cohort in korea
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291195/
https://www.ncbi.nlm.nih.gov/pubmed/33285050
http://dx.doi.org/10.4143/crt.2020.720
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