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GCH1 induces immunosuppression through metabolic reprogramming and IDO1 upregulation in triple-negative breast cancer

PURPOSE: Regulatory T cells (Tregs) heavily infiltrate triple-negative breast cancer (TNBC), and their accumulation is affected by the metabolic reprogramming in cancer cells. In the present study, we sought to identify cancer cell-intrinsic metabolic modulators correlating with Tregs infiltration i...

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Detalles Bibliográficos
Autores principales:	Wei, Jin-Li, Wu, Si-Yu, Yang, Yun-Song, Xiao, Yi, Jin, Xi, Xu, Xiao-En, Hu, Xin, Li, Da-Qiang, Jiang, Yi-Zhou, Shao, Zhi-Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2021
Materias:	Basic Tumor Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291318/ https://www.ncbi.nlm.nih.gov/pubmed/34281987 http://dx.doi.org/10.1136/jitc-2021-002383

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