Mutations at the M2 and M3 Transmembrane Helices of the GABA(A)Rs α(1) and β(2) Subunits Affect Primarily Late Gating Transitions Including Opening/Closing and Desensitization

[Image: see text] GABA type A receptors (GABA(A)Rs) belong to the pentameric ligand-gated ion channel (pLGIC) family and play a crucial role in mediating inhibition in the adult mammalian brain. Recently, a major progress in determining the static structure of GABA(A)Rs was achieved, although precis...

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Autores principales: Terejko, Katarzyna, Michałowski, Michał A., Iżykowska, Ilona, Dominik, Anna, Brzóstowicz, Aleksandra, Mozrzymas, Jerzy W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291490/
https://www.ncbi.nlm.nih.gov/pubmed/34101432
http://dx.doi.org/10.1021/acschemneuro.1c00151

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