BMAL1 knockout macaque monkeys display reduced sleep and psychiatric disorders

Circadian disruption is a risk factor for metabolic, psychiatric and age-related disorders, and non-human primate models could help to develop therapeutic treatments. Here, we report the generation of BMAL1 knockout cynomolgus monkeys for circadian-related disorders by CRISPR/Cas9 editing of monkey...

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Detalles Bibliográficos
Autores principales: Qiu, Peiyuan, Jiang, Jian, Liu, Zhen, Cai, Yijun, Huang, Tao, Wang, Yan, Liu, Qiming, Nie, Yanhong, Liu, Fang, Cheng, Jiumu, Li, Qing, Tang, Yun-Chi, Poo, Mu-ming, Sun, Qiang, Chang, Hung-Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291534/
https://www.ncbi.nlm.nih.gov/pubmed/34691834
http://dx.doi.org/10.1093/nsr/nwz002

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