Advances in Biological Functions and Clinical Studies of FGF21

Fibroblast growth factor 21 (FGF21) regulates many crucial biological processes in human and mammals, particularly metabolic modulation and protective effect after injury. Therefore, determining complex regulatory mechanisms and elucidating the signaling pathway may greatly promote the prevention, d...

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Detalles Bibliográficos
Autores principales: Lin, Wei, Zhang, Tianlei, Zhou, Yiyang, Zheng, Jinyu, Lin, Zhenlang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291585/
https://www.ncbi.nlm.nih.gov/pubmed/34295169
http://dx.doi.org/10.2147/DMSO.S317096
Descripción
Sumario:Fibroblast growth factor 21 (FGF21) regulates many crucial biological processes in human and mammals, particularly metabolic modulation and protective effect after injury. Therefore, determining complex regulatory mechanisms and elucidating the signaling pathway may greatly promote the prevention, diagnosis, and treatment of related injury and metabolic diseases. This review focused on the metabolic modulation and protective effect of FGF21 and summarized the molecular mechanisms and clinical research developments.

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