Advances in Biological Functions and Clinical Studies of FGF21

Fibroblast growth factor 21 (FGF21) regulates many crucial biological processes in human and mammals, particularly metabolic modulation and protective effect after injury. Therefore, determining complex regulatory mechanisms and elucidating the signaling pathway may greatly promote the prevention, d...

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Detalles Bibliográficos
Autores principales: Lin, Wei, Zhang, Tianlei, Zhou, Yiyang, Zheng, Jinyu, Lin, Zhenlang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291585/
https://www.ncbi.nlm.nih.gov/pubmed/34295169
http://dx.doi.org/10.2147/DMSO.S317096
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author Lin, Wei
Zhang, Tianlei
Zhou, Yiyang
Zheng, Jinyu
Lin, Zhenlang
author_facet Lin, Wei
Zhang, Tianlei
Zhou, Yiyang
Zheng, Jinyu
Lin, Zhenlang
author_sort Lin, Wei
collection PubMed
description Fibroblast growth factor 21 (FGF21) regulates many crucial biological processes in human and mammals, particularly metabolic modulation and protective effect after injury. Therefore, determining complex regulatory mechanisms and elucidating the signaling pathway may greatly promote the prevention, diagnosis, and treatment of related injury and metabolic diseases. This review focused on the metabolic modulation and protective effect of FGF21 and summarized the molecular mechanisms and clinical research developments.
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spelling pubmed-82915852021-07-21 Advances in Biological Functions and Clinical Studies of FGF21 Lin, Wei Zhang, Tianlei Zhou, Yiyang Zheng, Jinyu Lin, Zhenlang Diabetes Metab Syndr Obes Review Fibroblast growth factor 21 (FGF21) regulates many crucial biological processes in human and mammals, particularly metabolic modulation and protective effect after injury. Therefore, determining complex regulatory mechanisms and elucidating the signaling pathway may greatly promote the prevention, diagnosis, and treatment of related injury and metabolic diseases. This review focused on the metabolic modulation and protective effect of FGF21 and summarized the molecular mechanisms and clinical research developments. Dove 2021-07-16 /pmc/articles/PMC8291585/ /pubmed/34295169 http://dx.doi.org/10.2147/DMSO.S317096 Text en © 2021 Lin et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Lin, Wei
Zhang, Tianlei
Zhou, Yiyang
Zheng, Jinyu
Lin, Zhenlang
Advances in Biological Functions and Clinical Studies of FGF21
title Advances in Biological Functions and Clinical Studies of FGF21
title_full Advances in Biological Functions and Clinical Studies of FGF21
title_fullStr Advances in Biological Functions and Clinical Studies of FGF21
title_full_unstemmed Advances in Biological Functions and Clinical Studies of FGF21
title_short Advances in Biological Functions and Clinical Studies of FGF21
title_sort advances in biological functions and clinical studies of fgf21
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291585/
https://www.ncbi.nlm.nih.gov/pubmed/34295169
http://dx.doi.org/10.2147/DMSO.S317096
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