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Improved glycaemia during the Covid-19 pandemic lockdown is sustained post-lockdown and during the “Eat Out to Help Out” Government Scheme, in adults with Type 1 diabetes in the United Kingdom

AIMS: The majority of studies report that the Covid-19 pandemic lockdown did not have a detrimental effect on glycaemia. We sought to explore the impact of lockdown on glycaemia and whether this is sustained following easing of restrictions. METHODS: Retrospective, observational analysis in adults a...

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Autores principales: Avari, Parizad, Unsworth, Rebecca, Rilstone, Siân, Uduku, Chukwuma, Logan, Karen M., Hill, Neil E., Godsland, Ian F., Reddy, Monika, Oliver, Nick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291633/
https://www.ncbi.nlm.nih.gov/pubmed/34283880
http://dx.doi.org/10.1371/journal.pone.0254951
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author Avari, Parizad
Unsworth, Rebecca
Rilstone, Siân
Uduku, Chukwuma
Logan, Karen M.
Hill, Neil E.
Godsland, Ian F.
Reddy, Monika
Oliver, Nick
author_facet Avari, Parizad
Unsworth, Rebecca
Rilstone, Siân
Uduku, Chukwuma
Logan, Karen M.
Hill, Neil E.
Godsland, Ian F.
Reddy, Monika
Oliver, Nick
author_sort Avari, Parizad
collection PubMed
description AIMS: The majority of studies report that the Covid-19 pandemic lockdown did not have a detrimental effect on glycaemia. We sought to explore the impact of lockdown on glycaemia and whether this is sustained following easing of restrictions. METHODS: Retrospective, observational analysis in adults and children with type 1 diabetes attending a UK specialist centre, using real-time or intermittently scanned continuous glucose monitoring. Data from the following 28-day time periods were collected: (i) pre-lockdown; (ii) during lockdown; (iii) immediately after lockdown; and (iv) a month following relaxation of restrictions (coinciding with Government-subsidised restaurant food). Data were analysed for times in glycaemic ranges and are expressed as median (IQR). RESULTS: 145 adults aged 35.5 (25.8–51.3) years with diabetes duration of 19.0 (7.0–29.0) years on multiple daily injections of insulin (60%) and continuous insulin infusion (40%) were included. In adults, % time in range (70-180mg/dL) increased during lockdown (60.2 (45.2–69.3)%) compared to pre-lockdown (56.7 (43.5–65.3)%; p<0.001). This was maintained in the post-lockdown time periods. Similarly, % time above range (>180mg/dL) reduced in lockdown compared to pre-lockdown (p = 0.01), which was sustained thereafter. In children, no significant changes to glycaemia were observed during lockdown. In multivariable analysis, a greater increase in %TIR 3.9-10mmol/L (70-180mg/dL) during lockdown was associated with higher levels of deprivation (coefficient: 4.208, 95% CI 0.588 to 7.828; p = 0.02). CONCLUSIONS: Glycaemia in adults improved during lockdown, with people from more deprived areas most likely to benefit. This effect was sustained after easing of restrictions, with government-subsidised restaurant eating having no adverse impact on glycaemia.
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spelling pubmed-82916332021-07-31 Improved glycaemia during the Covid-19 pandemic lockdown is sustained post-lockdown and during the “Eat Out to Help Out” Government Scheme, in adults with Type 1 diabetes in the United Kingdom Avari, Parizad Unsworth, Rebecca Rilstone, Siân Uduku, Chukwuma Logan, Karen M. Hill, Neil E. Godsland, Ian F. Reddy, Monika Oliver, Nick PLoS One Research Article AIMS: The majority of studies report that the Covid-19 pandemic lockdown did not have a detrimental effect on glycaemia. We sought to explore the impact of lockdown on glycaemia and whether this is sustained following easing of restrictions. METHODS: Retrospective, observational analysis in adults and children with type 1 diabetes attending a UK specialist centre, using real-time or intermittently scanned continuous glucose monitoring. Data from the following 28-day time periods were collected: (i) pre-lockdown; (ii) during lockdown; (iii) immediately after lockdown; and (iv) a month following relaxation of restrictions (coinciding with Government-subsidised restaurant food). Data were analysed for times in glycaemic ranges and are expressed as median (IQR). RESULTS: 145 adults aged 35.5 (25.8–51.3) years with diabetes duration of 19.0 (7.0–29.0) years on multiple daily injections of insulin (60%) and continuous insulin infusion (40%) were included. In adults, % time in range (70-180mg/dL) increased during lockdown (60.2 (45.2–69.3)%) compared to pre-lockdown (56.7 (43.5–65.3)%; p<0.001). This was maintained in the post-lockdown time periods. Similarly, % time above range (>180mg/dL) reduced in lockdown compared to pre-lockdown (p = 0.01), which was sustained thereafter. In children, no significant changes to glycaemia were observed during lockdown. In multivariable analysis, a greater increase in %TIR 3.9-10mmol/L (70-180mg/dL) during lockdown was associated with higher levels of deprivation (coefficient: 4.208, 95% CI 0.588 to 7.828; p = 0.02). CONCLUSIONS: Glycaemia in adults improved during lockdown, with people from more deprived areas most likely to benefit. This effect was sustained after easing of restrictions, with government-subsidised restaurant eating having no adverse impact on glycaemia. Public Library of Science 2021-07-20 /pmc/articles/PMC8291633/ /pubmed/34283880 http://dx.doi.org/10.1371/journal.pone.0254951 Text en © 2021 Avari et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Avari, Parizad
Unsworth, Rebecca
Rilstone, Siân
Uduku, Chukwuma
Logan, Karen M.
Hill, Neil E.
Godsland, Ian F.
Reddy, Monika
Oliver, Nick
Improved glycaemia during the Covid-19 pandemic lockdown is sustained post-lockdown and during the “Eat Out to Help Out” Government Scheme, in adults with Type 1 diabetes in the United Kingdom
title Improved glycaemia during the Covid-19 pandemic lockdown is sustained post-lockdown and during the “Eat Out to Help Out” Government Scheme, in adults with Type 1 diabetes in the United Kingdom
title_full Improved glycaemia during the Covid-19 pandemic lockdown is sustained post-lockdown and during the “Eat Out to Help Out” Government Scheme, in adults with Type 1 diabetes in the United Kingdom
title_fullStr Improved glycaemia during the Covid-19 pandemic lockdown is sustained post-lockdown and during the “Eat Out to Help Out” Government Scheme, in adults with Type 1 diabetes in the United Kingdom
title_full_unstemmed Improved glycaemia during the Covid-19 pandemic lockdown is sustained post-lockdown and during the “Eat Out to Help Out” Government Scheme, in adults with Type 1 diabetes in the United Kingdom
title_short Improved glycaemia during the Covid-19 pandemic lockdown is sustained post-lockdown and during the “Eat Out to Help Out” Government Scheme, in adults with Type 1 diabetes in the United Kingdom
title_sort improved glycaemia during the covid-19 pandemic lockdown is sustained post-lockdown and during the “eat out to help out” government scheme, in adults with type 1 diabetes in the united kingdom
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291633/
https://www.ncbi.nlm.nih.gov/pubmed/34283880
http://dx.doi.org/10.1371/journal.pone.0254951
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