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Transcriptomic and epigenomic profiling of young and aged spermatogonial stem cells reveals molecular targets regulating differentiation

Spermatogonial stem cells (SSC), the foundation of spermatogenesis and male fertility, possess lifelong self-renewal activity. Aging leads to the decline in stem cell function and increased risk of paternal age-related genetic diseases. In the present study, we performed a comparative genomic analys...

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Detalles Bibliográficos
Autores principales:	Liao, Jinyue, Suen, Hoi Ching, Luk, Alfred Chun Shui, Yang, Lele, Lee, Annie Wing Tung, Qi, Huayu, Lee, Tin-Lap
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291634/ https://www.ncbi.nlm.nih.gov/pubmed/34237055 http://dx.doi.org/10.1371/journal.pgen.1009369

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