Cargando…

TB@PLGA Nanoparticles for Photodynamic/Photothermal Combined Cancer Therapy with Single Near-Infrared Irradiation

BACKGROUND: Phototherapy has significant potential as an effective treatment for cancer. However, the application of a multifunctional nanoplatform for photodynamic therapy (PDT) and photothermal therapy (PTT) at a single excitation wavelength remains a challenge. MATERIALS AND METHODS: The double e...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Yue, Tang, Taya, Liu, Bo, Tian, Jijing, Wu, Haiyan, Liu, Zhongjie, Liu, Zhaoping, Zhang, Lei, Bao, Huihui, Liu, Tianlong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291662/
https://www.ncbi.nlm.nih.gov/pubmed/34295159
http://dx.doi.org/10.2147/IJN.S304713
_version_ 1783724685639286784
author Yang, Yue
Tang, Taya
Liu, Bo
Tian, Jijing
Wu, Haiyan
Liu, Zhongjie
Liu, Zhaoping
Zhang, Lei
Bao, Huihui
Liu, Tianlong
author_facet Yang, Yue
Tang, Taya
Liu, Bo
Tian, Jijing
Wu, Haiyan
Liu, Zhongjie
Liu, Zhaoping
Zhang, Lei
Bao, Huihui
Liu, Tianlong
author_sort Yang, Yue
collection PubMed
description BACKGROUND: Phototherapy has significant potential as an effective treatment for cancer. However, the application of a multifunctional nanoplatform for photodynamic therapy (PDT) and photothermal therapy (PTT) at a single excitation wavelength remains a challenge. MATERIALS AND METHODS: The double emulsion solvent evaporation method was used to prepare toluidine blue@poly lactic-co-glycolic acid (TB@PLGA) nanoparticles (NPs). The biocompatibility of TB@PLGA NPs was evaluated, and a 660 nm luminescence was used as the light source. The photothermal effect, photothermal stability, and singlet oxygen yield of NPs in an aqueous solution verified the feasibility of NPs as a PTT/PDT synergistic therapy drug. RESULTS: TB@PLGA NPs were successfully prepared and characterized. In vitro experiments demonstrated that TB@PLGA NPs can cause massive necrosis of tumor cells and induce apoptosis through a photodynamic mechanism under 660 nm laser irradiation. The TB@PLGA NPs also achieved optimal tumor inhibition effect in vivo. CONCLUSION: The TB@PLGA NPs prepared in this study were applied as a dual-mode phototherapeutic agent under single laser irradiation. Both in vitro and in vivo experiments demonstrated the good potential of PTT/PDT for tumor inhibitors.
format Online
Article
Text
id pubmed-8291662
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-82916622021-07-21 TB@PLGA Nanoparticles for Photodynamic/Photothermal Combined Cancer Therapy with Single Near-Infrared Irradiation Yang, Yue Tang, Taya Liu, Bo Tian, Jijing Wu, Haiyan Liu, Zhongjie Liu, Zhaoping Zhang, Lei Bao, Huihui Liu, Tianlong Int J Nanomedicine Original Research BACKGROUND: Phototherapy has significant potential as an effective treatment for cancer. However, the application of a multifunctional nanoplatform for photodynamic therapy (PDT) and photothermal therapy (PTT) at a single excitation wavelength remains a challenge. MATERIALS AND METHODS: The double emulsion solvent evaporation method was used to prepare toluidine blue@poly lactic-co-glycolic acid (TB@PLGA) nanoparticles (NPs). The biocompatibility of TB@PLGA NPs was evaluated, and a 660 nm luminescence was used as the light source. The photothermal effect, photothermal stability, and singlet oxygen yield of NPs in an aqueous solution verified the feasibility of NPs as a PTT/PDT synergistic therapy drug. RESULTS: TB@PLGA NPs were successfully prepared and characterized. In vitro experiments demonstrated that TB@PLGA NPs can cause massive necrosis of tumor cells and induce apoptosis through a photodynamic mechanism under 660 nm laser irradiation. The TB@PLGA NPs also achieved optimal tumor inhibition effect in vivo. CONCLUSION: The TB@PLGA NPs prepared in this study were applied as a dual-mode phototherapeutic agent under single laser irradiation. Both in vitro and in vivo experiments demonstrated the good potential of PTT/PDT for tumor inhibitors. Dove 2021-07-16 /pmc/articles/PMC8291662/ /pubmed/34295159 http://dx.doi.org/10.2147/IJN.S304713 Text en © 2021 Yang et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Yang, Yue
Tang, Taya
Liu, Bo
Tian, Jijing
Wu, Haiyan
Liu, Zhongjie
Liu, Zhaoping
Zhang, Lei
Bao, Huihui
Liu, Tianlong
TB@PLGA Nanoparticles for Photodynamic/Photothermal Combined Cancer Therapy with Single Near-Infrared Irradiation
title TB@PLGA Nanoparticles for Photodynamic/Photothermal Combined Cancer Therapy with Single Near-Infrared Irradiation
title_full TB@PLGA Nanoparticles for Photodynamic/Photothermal Combined Cancer Therapy with Single Near-Infrared Irradiation
title_fullStr TB@PLGA Nanoparticles for Photodynamic/Photothermal Combined Cancer Therapy with Single Near-Infrared Irradiation
title_full_unstemmed TB@PLGA Nanoparticles for Photodynamic/Photothermal Combined Cancer Therapy with Single Near-Infrared Irradiation
title_short TB@PLGA Nanoparticles for Photodynamic/Photothermal Combined Cancer Therapy with Single Near-Infrared Irradiation
title_sort tb@plga nanoparticles for photodynamic/photothermal combined cancer therapy with single near-infrared irradiation
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291662/
https://www.ncbi.nlm.nih.gov/pubmed/34295159
http://dx.doi.org/10.2147/IJN.S304713
work_keys_str_mv AT yangyue tbplgananoparticlesforphotodynamicphotothermalcombinedcancertherapywithsinglenearinfraredirradiation
AT tangtaya tbplgananoparticlesforphotodynamicphotothermalcombinedcancertherapywithsinglenearinfraredirradiation
AT liubo tbplgananoparticlesforphotodynamicphotothermalcombinedcancertherapywithsinglenearinfraredirradiation
AT tianjijing tbplgananoparticlesforphotodynamicphotothermalcombinedcancertherapywithsinglenearinfraredirradiation
AT wuhaiyan tbplgananoparticlesforphotodynamicphotothermalcombinedcancertherapywithsinglenearinfraredirradiation
AT liuzhongjie tbplgananoparticlesforphotodynamicphotothermalcombinedcancertherapywithsinglenearinfraredirradiation
AT liuzhaoping tbplgananoparticlesforphotodynamicphotothermalcombinedcancertherapywithsinglenearinfraredirradiation
AT zhanglei tbplgananoparticlesforphotodynamicphotothermalcombinedcancertherapywithsinglenearinfraredirradiation
AT baohuihui tbplgananoparticlesforphotodynamicphotothermalcombinedcancertherapywithsinglenearinfraredirradiation
AT liutianlong tbplgananoparticlesforphotodynamicphotothermalcombinedcancertherapywithsinglenearinfraredirradiation