α-Synuclein fibrils subvert lysosome structure and function for the propagation of protein misfolding between cells through tunneling nanotubes

The accumulation of α-synuclein (α-syn) aggregates in specific brain regions is a hallmark of synucleinopathies including Parkinson disease (PD). α-Syn aggregates propagate in a “prion-like” manner and can be transferred inside lysosomes to recipient cells through tunneling nanotubes (TNTs). However...

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Detalles Bibliográficos
Autores principales: Dilsizoglu Senol, Aysegul, Samarani, Maura, Syan, Sylvie, Guardia, Carlos M., Nonaka, Takashi, Liv, Nalan, Latour-Lambert, Patricia, Hasegawa, Masato, Klumperman, Judith, Bonifacino, Juan S., Zurzolo, Chiara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291706/
https://www.ncbi.nlm.nih.gov/pubmed/34283825
http://dx.doi.org/10.1371/journal.pbio.3001287

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