The beneficial role of vitamin B12 in injury induced by ischemia/reperfusion: Beyond scavenging superoxide?

Vitamin B12 (B12) is required for cellular metabolism and DNA synthesis as a co-enzyme; it also possesses anti-reactive oxygen species (ROS) property as a superoxide scavenger. B12 deficiency has been implicated in multiple diseases such as megaloblastic anemia, and this disease can be effectively c...

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Detalles Bibliográficos
Autor principal: Li, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291747/
https://www.ncbi.nlm.nih.gov/pubmed/34291234
http://dx.doi.org/10.46439/nephrology.2.007
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author Li, Feng
author_facet Li, Feng
author_sort Li, Feng
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description Vitamin B12 (B12) is required for cellular metabolism and DNA synthesis as a co-enzyme; it also possesses anti-reactive oxygen species (ROS) property as a superoxide scavenger. B12 deficiency has been implicated in multiple diseases such as megaloblastic anemia, and this disease can be effectively cured by supplementation of B12. Multiple studies suggest that B12 also benefits the conditions associated with excess ROS. Recently, we have reported that oral high dose B12 decreases superoxide level and renal injury induced by ischemia/reperfusion in mice. Here, we discuss potential mechanism(s) other than decreasing superoxide by which B12 executes its beneficial effects.
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spelling pubmed-82917472021-07-20 The beneficial role of vitamin B12 in injury induced by ischemia/reperfusion: Beyond scavenging superoxide? Li, Feng J Exp Nephrol Article Vitamin B12 (B12) is required for cellular metabolism and DNA synthesis as a co-enzyme; it also possesses anti-reactive oxygen species (ROS) property as a superoxide scavenger. B12 deficiency has been implicated in multiple diseases such as megaloblastic anemia, and this disease can be effectively cured by supplementation of B12. Multiple studies suggest that B12 also benefits the conditions associated with excess ROS. Recently, we have reported that oral high dose B12 decreases superoxide level and renal injury induced by ischemia/reperfusion in mice. Here, we discuss potential mechanism(s) other than decreasing superoxide by which B12 executes its beneficial effects. 2021 /pmc/articles/PMC8291747/ /pubmed/34291234 http://dx.doi.org/10.46439/nephrology.2.007 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Li, Feng
The beneficial role of vitamin B12 in injury induced by ischemia/reperfusion: Beyond scavenging superoxide?
title The beneficial role of vitamin B12 in injury induced by ischemia/reperfusion: Beyond scavenging superoxide?
title_full The beneficial role of vitamin B12 in injury induced by ischemia/reperfusion: Beyond scavenging superoxide?
title_fullStr The beneficial role of vitamin B12 in injury induced by ischemia/reperfusion: Beyond scavenging superoxide?
title_full_unstemmed The beneficial role of vitamin B12 in injury induced by ischemia/reperfusion: Beyond scavenging superoxide?
title_short The beneficial role of vitamin B12 in injury induced by ischemia/reperfusion: Beyond scavenging superoxide?
title_sort beneficial role of vitamin b12 in injury induced by ischemia/reperfusion: beyond scavenging superoxide?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291747/
https://www.ncbi.nlm.nih.gov/pubmed/34291234
http://dx.doi.org/10.46439/nephrology.2.007
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