Mitochondrial serine protease Omi/HtrA2 accentuates brain ischemia/reperfusion injury in rats and oxidative stress injury in vitro by modulating mitochondrial stress proteins CHOP and ClpP and physically interacting with mitochondrial fusion protein OPA1

Serine protease Omi/HtrA2, a member of the HtrA family, is closely related to the maintenance of mitochondrial integrity and participates in apoptosis but its role in cerebral ischemia/reperfusion (I/R) injury and cellular oxidative stress response remains unclear. In this study, we found that I/R i...

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Detalles Bibliográficos
Autores principales: You, Hailong, Jin, Yao, Kang, Jinsong, Mao, Ying, Su, Jing, Sun, Liankun, Wang, Li, Meng, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291814/
https://www.ncbi.nlm.nih.gov/pubmed/33016225
http://dx.doi.org/10.1080/21655979.2020.1822105

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