Could cytokine release syndrome induce acute myelofibrosis in CD19 chimeric antigen receptor T cells therapy?

CAR-T cells therapy can give rise to most common and concerning two side effects – cytokine release syndrome (CRS) and neurotoxicity. But in our CD19 CAR-T cells therapy clinical trial, we observed 1 out of 17 patients with B-cell acute lymphoblastic leukemia (B-ALL) developed acute myelofibrosis(AM...

Descripción completa

Detalles Bibliográficos
Autores principales: Lai, Xun, Sun, Yun Yan, Chang, Lung Ji, Ma, Yu Ru, Gu, Xue Zhong, Yao, Xiang Mei, Nie, Bo, Wen, Yan, Zhang, Xue Mei, Jiang, Ya Xian, Yang, Hui, Yu, Li Qun, Fang, Ming Jing, Wang, Ling, Yuan Bo, Xue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291836/
https://www.ncbi.nlm.nih.gov/pubmed/32772769
http://dx.doi.org/10.1080/21655979.2020.1791597
_version_ 1783724720508633088
author Lai, Xun
Sun, Yun Yan
Chang, Lung Ji
Ma, Yu Ru
Gu, Xue Zhong
Yao, Xiang Mei
Nie, Bo
Wen, Yan
Zhang, Xue Mei
Jiang, Ya Xian
Yang, Hui
Yu, Li Qun
Fang, Ming Jing
Wang, Ling
Yuan Bo, Xue
author_facet Lai, Xun
Sun, Yun Yan
Chang, Lung Ji
Ma, Yu Ru
Gu, Xue Zhong
Yao, Xiang Mei
Nie, Bo
Wen, Yan
Zhang, Xue Mei
Jiang, Ya Xian
Yang, Hui
Yu, Li Qun
Fang, Ming Jing
Wang, Ling
Yuan Bo, Xue
author_sort Lai, Xun
collection PubMed
description CAR-T cells therapy can give rise to most common and concerning two side effects – cytokine release syndrome (CRS) and neurotoxicity. But in our CD19 CAR-T cells therapy clinical trial, we observed 1 out of 17 patients with B-cell acute lymphoblastic leukemia (B-ALL) developed acute myelofibrosis(AMF) after grade IV CRS post to the CD19 CAR-T cells therapy. This finding suggests that the CAR-T cells therapy may have rare and serious AMF, which we should pay important attention to. Trial registration:NCT02968472. Registered 18 November 2016 – Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT02968472
format Online
Article
Text
id pubmed-8291836
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-82918362021-08-10 Could cytokine release syndrome induce acute myelofibrosis in CD19 chimeric antigen receptor T cells therapy? Lai, Xun Sun, Yun Yan Chang, Lung Ji Ma, Yu Ru Gu, Xue Zhong Yao, Xiang Mei Nie, Bo Wen, Yan Zhang, Xue Mei Jiang, Ya Xian Yang, Hui Yu, Li Qun Fang, Ming Jing Wang, Ling Yuan Bo, Xue Bioengineered Research Paper CAR-T cells therapy can give rise to most common and concerning two side effects – cytokine release syndrome (CRS) and neurotoxicity. But in our CD19 CAR-T cells therapy clinical trial, we observed 1 out of 17 patients with B-cell acute lymphoblastic leukemia (B-ALL) developed acute myelofibrosis(AMF) after grade IV CRS post to the CD19 CAR-T cells therapy. This finding suggests that the CAR-T cells therapy may have rare and serious AMF, which we should pay important attention to. Trial registration:NCT02968472. Registered 18 November 2016 – Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT02968472 Taylor & Francis 2020-08-10 /pmc/articles/PMC8291836/ /pubmed/32772769 http://dx.doi.org/10.1080/21655979.2020.1791597 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Lai, Xun
Sun, Yun Yan
Chang, Lung Ji
Ma, Yu Ru
Gu, Xue Zhong
Yao, Xiang Mei
Nie, Bo
Wen, Yan
Zhang, Xue Mei
Jiang, Ya Xian
Yang, Hui
Yu, Li Qun
Fang, Ming Jing
Wang, Ling
Yuan Bo, Xue
Could cytokine release syndrome induce acute myelofibrosis in CD19 chimeric antigen receptor T cells therapy?
title Could cytokine release syndrome induce acute myelofibrosis in CD19 chimeric antigen receptor T cells therapy?
title_full Could cytokine release syndrome induce acute myelofibrosis in CD19 chimeric antigen receptor T cells therapy?
title_fullStr Could cytokine release syndrome induce acute myelofibrosis in CD19 chimeric antigen receptor T cells therapy?
title_full_unstemmed Could cytokine release syndrome induce acute myelofibrosis in CD19 chimeric antigen receptor T cells therapy?
title_short Could cytokine release syndrome induce acute myelofibrosis in CD19 chimeric antigen receptor T cells therapy?
title_sort could cytokine release syndrome induce acute myelofibrosis in cd19 chimeric antigen receptor t cells therapy?
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291836/
https://www.ncbi.nlm.nih.gov/pubmed/32772769
http://dx.doi.org/10.1080/21655979.2020.1791597
work_keys_str_mv AT laixun couldcytokinereleasesyndromeinduceacutemyelofibrosisincd19chimericantigenreceptortcellstherapy
AT sunyunyan couldcytokinereleasesyndromeinduceacutemyelofibrosisincd19chimericantigenreceptortcellstherapy
AT changlungji couldcytokinereleasesyndromeinduceacutemyelofibrosisincd19chimericantigenreceptortcellstherapy
AT mayuru couldcytokinereleasesyndromeinduceacutemyelofibrosisincd19chimericantigenreceptortcellstherapy
AT guxuezhong couldcytokinereleasesyndromeinduceacutemyelofibrosisincd19chimericantigenreceptortcellstherapy
AT yaoxiangmei couldcytokinereleasesyndromeinduceacutemyelofibrosisincd19chimericantigenreceptortcellstherapy
AT niebo couldcytokinereleasesyndromeinduceacutemyelofibrosisincd19chimericantigenreceptortcellstherapy
AT wenyan couldcytokinereleasesyndromeinduceacutemyelofibrosisincd19chimericantigenreceptortcellstherapy
AT zhangxuemei couldcytokinereleasesyndromeinduceacutemyelofibrosisincd19chimericantigenreceptortcellstherapy
AT jiangyaxian couldcytokinereleasesyndromeinduceacutemyelofibrosisincd19chimericantigenreceptortcellstherapy
AT yanghui couldcytokinereleasesyndromeinduceacutemyelofibrosisincd19chimericantigenreceptortcellstherapy
AT yuliqun couldcytokinereleasesyndromeinduceacutemyelofibrosisincd19chimericantigenreceptortcellstherapy
AT fangmingjing couldcytokinereleasesyndromeinduceacutemyelofibrosisincd19chimericantigenreceptortcellstherapy
AT wangling couldcytokinereleasesyndromeinduceacutemyelofibrosisincd19chimericantigenreceptortcellstherapy
AT yuanboxue couldcytokinereleasesyndromeinduceacutemyelofibrosisincd19chimericantigenreceptortcellstherapy

Ejemplares similares