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Recent advances in synthetic biology of cyanobacteria for improved chemicals production
Cyanobacteria are Gram-negative photoautotrophic prokaryotes and have shown great importance to the Earth’s ecology. Based on their capability in oxygenic photosynthesis and genetic merits, they can be engineered as microbial chassis for direct conversion of carbon dioxide to value-added biofuels an...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Taylor & Francis
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291842/ https://www.ncbi.nlm.nih.gov/pubmed/33124500 http://dx.doi.org/10.1080/21655979.2020.1837458 |
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author | Wang, Fen Gao, Yuanyuan Yang, Guang |
author_facet | Wang, Fen Gao, Yuanyuan Yang, Guang |
author_sort | Wang, Fen |
collection | PubMed |
description | Cyanobacteria are Gram-negative photoautotrophic prokaryotes and have shown great importance to the Earth’s ecology. Based on their capability in oxygenic photosynthesis and genetic merits, they can be engineered as microbial chassis for direct conversion of carbon dioxide to value-added biofuels and chemicals. In the last decades, attempts have given to the application of synthetic biology tools and approaches in the development of cyanobacterial cell factories. Despite the successful proof-of-principle studies, large-scale application is still a technical challenge due to low yields of bioproducts. Therefore, recent efforts are underway to characterize and develop genetic regulatory parts and strategies for the synthetic biology applications in cyanobacteria. In this review, we present the recent advancements and application in cyanobacterial synthetic biology toolboxes. We also discuss the limitations and future perspectives for using such novel tools in cyanobacterial biotechnology. |
format | Online Article Text |
id | pubmed-8291842 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-82918422021-09-01 Recent advances in synthetic biology of cyanobacteria for improved chemicals production Wang, Fen Gao, Yuanyuan Yang, Guang Bioengineered Review Cyanobacteria are Gram-negative photoautotrophic prokaryotes and have shown great importance to the Earth’s ecology. Based on their capability in oxygenic photosynthesis and genetic merits, they can be engineered as microbial chassis for direct conversion of carbon dioxide to value-added biofuels and chemicals. In the last decades, attempts have given to the application of synthetic biology tools and approaches in the development of cyanobacterial cell factories. Despite the successful proof-of-principle studies, large-scale application is still a technical challenge due to low yields of bioproducts. Therefore, recent efforts are underway to characterize and develop genetic regulatory parts and strategies for the synthetic biology applications in cyanobacteria. In this review, we present the recent advancements and application in cyanobacterial synthetic biology toolboxes. We also discuss the limitations and future perspectives for using such novel tools in cyanobacterial biotechnology. Taylor & Francis 2020-10-30 /pmc/articles/PMC8291842/ /pubmed/33124500 http://dx.doi.org/10.1080/21655979.2020.1837458 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Wang, Fen Gao, Yuanyuan Yang, Guang Recent advances in synthetic biology of cyanobacteria for improved chemicals production |
title | Recent advances in synthetic biology of cyanobacteria for improved chemicals production |
title_full | Recent advances in synthetic biology of cyanobacteria for improved chemicals production |
title_fullStr | Recent advances in synthetic biology of cyanobacteria for improved chemicals production |
title_full_unstemmed | Recent advances in synthetic biology of cyanobacteria for improved chemicals production |
title_short | Recent advances in synthetic biology of cyanobacteria for improved chemicals production |
title_sort | recent advances in synthetic biology of cyanobacteria for improved chemicals production |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291842/ https://www.ncbi.nlm.nih.gov/pubmed/33124500 http://dx.doi.org/10.1080/21655979.2020.1837458 |
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