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Circular RNA hsa_circ_0000034 promotes the progression of retinoblastoma via sponging microRNA-361-3p

Retinoblastoma is the commonest eye cancer occurring in the pediatric population. Circular RNAs (circRNAs) are essential regulators of tumorigenesis and development. The current experiment delves into the function and molecular basis of hsa_circ_0000034 in retinoblastoma progression. In the study, t...

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Detalles Bibliográficos
Autores principales: Sun, Zhe, Zhang, Ai, Hou, Mingyu, Jiang, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291869/
https://www.ncbi.nlm.nih.gov/pubmed/32892696
http://dx.doi.org/10.1080/21655979.2020.1814670
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author Sun, Zhe
Zhang, Ai
Hou, Mingyu
Jiang, Tao
author_facet Sun, Zhe
Zhang, Ai
Hou, Mingyu
Jiang, Tao
author_sort Sun, Zhe
collection PubMed
description Retinoblastoma is the commonest eye cancer occurring in the pediatric population. Circular RNAs (circRNAs) are essential regulators of tumorigenesis and development. The current experiment delves into the function and molecular basis of hsa_circ_0000034 in retinoblastoma progression. In the study, these series of experiments noted an upregulation of hsa_circ_0000034 in retinoblastoma cell lines and tissues. Retinoblastoma patients with raised hsa_circ_0000034 expressions were more likely to possess a more progressive International Integrated Reporting Council (IIRC) stage and optic nerve invasion. hsa_circ_0000034 knockdown caused a marked suppression in the proliferation and invasion of retinoblastoma cells in vitro. Mechanistically, hsa_circ_0000034 appeared to serve as a competitive endogenous RNA (ceRNA) in retinoblastoma through miR-361-3p sponging. In conclusion, our data proved that hsa_circ_0000034 promoted the oncogenicity of retinoblastoma via regulation of miR-361-3p expression, a finding that may contribute toward retinoblastoma therapeutics.
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spelling pubmed-82918692021-09-01 Circular RNA hsa_circ_0000034 promotes the progression of retinoblastoma via sponging microRNA-361-3p Sun, Zhe Zhang, Ai Hou, Mingyu Jiang, Tao Bioengineered Research Paper Retinoblastoma is the commonest eye cancer occurring in the pediatric population. Circular RNAs (circRNAs) are essential regulators of tumorigenesis and development. The current experiment delves into the function and molecular basis of hsa_circ_0000034 in retinoblastoma progression. In the study, these series of experiments noted an upregulation of hsa_circ_0000034 in retinoblastoma cell lines and tissues. Retinoblastoma patients with raised hsa_circ_0000034 expressions were more likely to possess a more progressive International Integrated Reporting Council (IIRC) stage and optic nerve invasion. hsa_circ_0000034 knockdown caused a marked suppression in the proliferation and invasion of retinoblastoma cells in vitro. Mechanistically, hsa_circ_0000034 appeared to serve as a competitive endogenous RNA (ceRNA) in retinoblastoma through miR-361-3p sponging. In conclusion, our data proved that hsa_circ_0000034 promoted the oncogenicity of retinoblastoma via regulation of miR-361-3p expression, a finding that may contribute toward retinoblastoma therapeutics. Taylor & Francis 2020-09-06 /pmc/articles/PMC8291869/ /pubmed/32892696 http://dx.doi.org/10.1080/21655979.2020.1814670 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Sun, Zhe
Zhang, Ai
Hou, Mingyu
Jiang, Tao
Circular RNA hsa_circ_0000034 promotes the progression of retinoblastoma via sponging microRNA-361-3p
title Circular RNA hsa_circ_0000034 promotes the progression of retinoblastoma via sponging microRNA-361-3p
title_full Circular RNA hsa_circ_0000034 promotes the progression of retinoblastoma via sponging microRNA-361-3p
title_fullStr Circular RNA hsa_circ_0000034 promotes the progression of retinoblastoma via sponging microRNA-361-3p
title_full_unstemmed Circular RNA hsa_circ_0000034 promotes the progression of retinoblastoma via sponging microRNA-361-3p
title_short Circular RNA hsa_circ_0000034 promotes the progression of retinoblastoma via sponging microRNA-361-3p
title_sort circular rna hsa_circ_0000034 promotes the progression of retinoblastoma via sponging microrna-361-3p
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291869/
https://www.ncbi.nlm.nih.gov/pubmed/32892696
http://dx.doi.org/10.1080/21655979.2020.1814670
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