The Regulatory Role of PRRX1 in Cancer Epithelial-Mesenchymal Transition

PRRX1 (paired related homeobox 1), a member of the paired homeobox family, exhibits an important role in tumor. It is closely correlated to the occurrence of epithelial-mesenchymal transition (EMT). PRRX1 is an important transcription factor regulating EMT and plays an important role in tumor progre...

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Detalles Bibliográficos
Autores principales: Du, Wenjiao, Liu, Xinchang, Yang, Man, Wang, Weipeng, Sun, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291965/
https://www.ncbi.nlm.nih.gov/pubmed/34295164
http://dx.doi.org/10.2147/OTT.S316102
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author Du, Wenjiao
Liu, Xinchang
Yang, Man
Wang, Weipeng
Sun, Jing
author_facet Du, Wenjiao
Liu, Xinchang
Yang, Man
Wang, Weipeng
Sun, Jing
author_sort Du, Wenjiao
collection PubMed
description PRRX1 (paired related homeobox 1), a member of the paired homeobox family, exhibits an important role in tumor. It is closely correlated to the occurrence of epithelial-mesenchymal transition (EMT). PRRX1 is an important transcription factor regulating EMT and plays an important role in tumor progression. In the process of tumor metastasis, PRRX1 mainly regulates the occurrence of EMT in tumor cells through TGF-β signaling pathway, Wnt/β-catenin signaling pathway and Notch signaling pathway. PRRX1 is not only closely related to the tumor cell stemness but also involved in miRNA regulation of EMT. Therefore, PRRX1 may be a target for inhibiting the proliferation, metastasis and stemness of tumor cells. The current review provides a systemic profile of the regulatory role of PRRX1 in cancer epithelial-mesenchymal transition.
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spelling pubmed-82919652021-07-21 The Regulatory Role of PRRX1 in Cancer Epithelial-Mesenchymal Transition Du, Wenjiao Liu, Xinchang Yang, Man Wang, Weipeng Sun, Jing Onco Targets Ther Review PRRX1 (paired related homeobox 1), a member of the paired homeobox family, exhibits an important role in tumor. It is closely correlated to the occurrence of epithelial-mesenchymal transition (EMT). PRRX1 is an important transcription factor regulating EMT and plays an important role in tumor progression. In the process of tumor metastasis, PRRX1 mainly regulates the occurrence of EMT in tumor cells through TGF-β signaling pathway, Wnt/β-catenin signaling pathway and Notch signaling pathway. PRRX1 is not only closely related to the tumor cell stemness but also involved in miRNA regulation of EMT. Therefore, PRRX1 may be a target for inhibiting the proliferation, metastasis and stemness of tumor cells. The current review provides a systemic profile of the regulatory role of PRRX1 in cancer epithelial-mesenchymal transition. Dove 2021-07-16 /pmc/articles/PMC8291965/ /pubmed/34295164 http://dx.doi.org/10.2147/OTT.S316102 Text en © 2021 Du et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Du, Wenjiao
Liu, Xinchang
Yang, Man
Wang, Weipeng
Sun, Jing
The Regulatory Role of PRRX1 in Cancer Epithelial-Mesenchymal Transition
title The Regulatory Role of PRRX1 in Cancer Epithelial-Mesenchymal Transition
title_full The Regulatory Role of PRRX1 in Cancer Epithelial-Mesenchymal Transition
title_fullStr The Regulatory Role of PRRX1 in Cancer Epithelial-Mesenchymal Transition
title_full_unstemmed The Regulatory Role of PRRX1 in Cancer Epithelial-Mesenchymal Transition
title_short The Regulatory Role of PRRX1 in Cancer Epithelial-Mesenchymal Transition
title_sort regulatory role of prrx1 in cancer epithelial-mesenchymal transition
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291965/
https://www.ncbi.nlm.nih.gov/pubmed/34295164
http://dx.doi.org/10.2147/OTT.S316102
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