Trojan horses and tunneling nanotubes enable α-synuclein pathology to spread in Parkinson disease

In Parkinson disease (PD), Lewy bodies (LBs) form in the gut or nose and spread into the midbrain. A study in this issue indicates that the spread is due to lysosomes “infected” with prion-like alpha-synuclein (α-syn) transmitting from cell to cell via tunneling nanotubes (TNTs).

Detalles Bibliográficos
Autores principales: Rajasekaran, Santhanasabapathy, Witt, Stephan N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Primer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291968/
https://www.ncbi.nlm.nih.gov/pubmed/34284485
http://dx.doi.org/10.1371/journal.pbio.3001331
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author Rajasekaran, Santhanasabapathy
Witt, Stephan N.
author_facet Rajasekaran, Santhanasabapathy
Witt, Stephan N.
author_sort Rajasekaran, Santhanasabapathy
collection PubMed
description In Parkinson disease (PD), Lewy bodies (LBs) form in the gut or nose and spread into the midbrain. A study in this issue indicates that the spread is due to lysosomes “infected” with prion-like alpha-synuclein (α-syn) transmitting from cell to cell via tunneling nanotubes (TNTs).
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spelling pubmed-82919682021-07-31 Trojan horses and tunneling nanotubes enable α-synuclein pathology to spread in Parkinson disease Rajasekaran, Santhanasabapathy Witt, Stephan N. PLoS Biol Primer In Parkinson disease (PD), Lewy bodies (LBs) form in the gut or nose and spread into the midbrain. A study in this issue indicates that the spread is due to lysosomes “infected” with prion-like alpha-synuclein (α-syn) transmitting from cell to cell via tunneling nanotubes (TNTs). Public Library of Science 2021-07-20 /pmc/articles/PMC8291968/ /pubmed/34284485 http://dx.doi.org/10.1371/journal.pbio.3001331 Text en © 2021 Rajasekaran, Witt https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Primer
Rajasekaran, Santhanasabapathy
Witt, Stephan N.
Trojan horses and tunneling nanotubes enable α-synuclein pathology to spread in Parkinson disease
title Trojan horses and tunneling nanotubes enable α-synuclein pathology to spread in Parkinson disease
title_full Trojan horses and tunneling nanotubes enable α-synuclein pathology to spread in Parkinson disease
title_fullStr Trojan horses and tunneling nanotubes enable α-synuclein pathology to spread in Parkinson disease
title_full_unstemmed Trojan horses and tunneling nanotubes enable α-synuclein pathology to spread in Parkinson disease
title_short Trojan horses and tunneling nanotubes enable α-synuclein pathology to spread in Parkinson disease
title_sort trojan horses and tunneling nanotubes enable α-synuclein pathology to spread in parkinson disease
topic Primer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291968/
https://www.ncbi.nlm.nih.gov/pubmed/34284485
http://dx.doi.org/10.1371/journal.pbio.3001331
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