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Trojan horses and tunneling nanotubes enable α-synuclein pathology to spread in Parkinson disease
In Parkinson disease (PD), Lewy bodies (LBs) form in the gut or nose and spread into the midbrain. A study in this issue indicates that the spread is due to lysosomes “infected” with prion-like alpha-synuclein (α-syn) transmitting from cell to cell via tunneling nanotubes (TNTs).
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291968/ https://www.ncbi.nlm.nih.gov/pubmed/34284485 http://dx.doi.org/10.1371/journal.pbio.3001331 |