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TNF-α-induced alterations in stromal progenitors enhance leukemic stem cell growth via CXCR2 signaling

Chronic myeloid leukemia (CML) is propagated by leukemia stem cells (LSCs) that are not eradicated by tyrosine kinase inhibitor (TKI) treatment and persist as a source of disease recurrence. Bone marrow (BM) mesenchymal niches play an essential role in hematopoietic stem cell (HSC) and LSC maintenan...

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Detalles Bibliográficos
Autores principales:	Agarwal, Puneet, Li, Hui, Choi, Kwangmin, Hueneman, Kathleen, He, Jianbo, Welner, Robert S., Starczynowski, Daniel T., Bhatia, Ravi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292106/ https://www.ncbi.nlm.nih.gov/pubmed/34260914 http://dx.doi.org/10.1016/j.celrep.2021.109386

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