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Atorvastatin pleiotropically decreases intraplaque angiogenesis and intraplaque haemorrhage by inhibiting ANGPT2 release and VE-Cadherin internalization

OBJECTIVE: Statins pleiotropically provide additional benefits in reducing atherosclerosis, but their effects on intraplaque angiogenesis (IPA) and hemorrhage (IPH) remain unclear. Therefore, we discriminated statin’s lipid-lowering dependent and independent effects on IPA and IPH. APPROACH AND RESU...

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Detalles Bibliográficos
Autores principales:	Baganha, Fabiana, de Jong, Rob C. M., Peters, Erna A., Voorham, Wietske, Jukema, J. Wouter, Delibegovic, Mirela, de Vries, Margreet R., Quax, Paul H. A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Netherlands 2021
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292290/ https://www.ncbi.nlm.nih.gov/pubmed/33550461 http://dx.doi.org/10.1007/s10456-021-09767-9

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