The endosomal RIN2/Rab5C machinery prevents VEGFR2 degradation to control gene expression and tip cell identity during angiogenesis

Sprouting angiogenesis is key to many pathophysiological conditions, and is strongly regulated by vascular endothelial growth factor (VEGF) signaling through VEGF receptor 2 (VEGFR2). Here we report that the early endosomal GTPase Rab5C and its activator RIN2 prevent lysosomal routing and degradatio...

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Detalles Bibliográficos
Autores principales: Kempers, Lanette, Wakayama, Yuki, van der Bijl, Ivo, Furumaya, Charita, De Cuyper, Iris M., Jongejan, Aldo, Kat, Marije, van Stalborch, Anne-Marieke D., van Boxtel, Antonius L., Hubert, Marvin, Geerts, Dirk, van Buul, Jaap D., de Korte, Dirk, Herzog, Wiebke, Margadant, Coert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2021
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292304/
https://www.ncbi.nlm.nih.gov/pubmed/33983539
http://dx.doi.org/10.1007/s10456-021-09788-4

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