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Concomitant oral intake of purified clinoptilolite tuff (G-PUR) reduces enteral lead uptake in healthy humans

Lead exposure can cause substantial organ damage. Enteral lead absorption may be reduced by concomitant intake of clinoptilolite tuff, a zeolite from natural sources. This study aimed to assess the effect of purified clinoptilolite tuff (G-PUR) on enteral lead uptake in adults using stable lead isot...

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Autores principales: Samekova, Karolina, Firbas, Christa, Irrgeher, Johanna, Opper, Christine, Prohaska, Thomas, Retzmann, Anika, Tschegg, Cornelius, Meisslitzer, Claudia, Tchaikovsky, Anastassiya, Gouya, Ghazaleh, Freissmuth, Michael, Wolzt, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292361/
https://www.ncbi.nlm.nih.gov/pubmed/34285282
http://dx.doi.org/10.1038/s41598-021-94245-x
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author Samekova, Karolina
Firbas, Christa
Irrgeher, Johanna
Opper, Christine
Prohaska, Thomas
Retzmann, Anika
Tschegg, Cornelius
Meisslitzer, Claudia
Tchaikovsky, Anastassiya
Gouya, Ghazaleh
Freissmuth, Michael
Wolzt, Michael
author_facet Samekova, Karolina
Firbas, Christa
Irrgeher, Johanna
Opper, Christine
Prohaska, Thomas
Retzmann, Anika
Tschegg, Cornelius
Meisslitzer, Claudia
Tchaikovsky, Anastassiya
Gouya, Ghazaleh
Freissmuth, Michael
Wolzt, Michael
author_sort Samekova, Karolina
collection PubMed
description Lead exposure can cause substantial organ damage. Enteral lead absorption may be reduced by concomitant intake of clinoptilolite tuff, a zeolite from natural sources. This study aimed to assess the effect of purified clinoptilolite tuff (G-PUR) on enteral lead uptake in adults using stable lead isotope (204)Pb as a tracer. In this randomized, placebo-controlled, double-blind, parallel-group study, 42 healthy participants were randomized to receive oral G-PUR 2.0 g, 2 * 2.0 g, or placebo, together with 2.5 µg of (204)Pb in water. The enrichment of (204)Pb caused by the tracer in blood and urine was measured by mass spectrometry. G-PUR was well tolerated. The mean maximum (204)Pb enrichment of 0.505% of total blood lead was significantly higher (p < 0.0001) in the placebo group compared to G-PUR 2.0 g (0.073%) or G-PUR 2 * 2.0 g (0.057%) group. Normalized (204)Pb AUC(0-192) was 86.5, 11.9, and 8.5% * h without and with G-PUR 2.0 g, and G-PUR 2 * 2.0 g, respectively (p < 0.0001 vs. placebo). This smaller (204)Pb exposure was paralleled by a reduced urinary excretion in subjects receiving G-PUR. Concomitant oral intake of purified clinoptilolite tuff reduced enteral uptake of (204)Pb in healthy humans by approximately 90%. The reduced bioavailability is demonstrable by a decrease of (204)Pb tracer enrichment in blood and urine. Trial registration: clinicaltrials.gov identifier: NCT04138693, registered 24/10/2019.
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spelling pubmed-82923612021-07-22 Concomitant oral intake of purified clinoptilolite tuff (G-PUR) reduces enteral lead uptake in healthy humans Samekova, Karolina Firbas, Christa Irrgeher, Johanna Opper, Christine Prohaska, Thomas Retzmann, Anika Tschegg, Cornelius Meisslitzer, Claudia Tchaikovsky, Anastassiya Gouya, Ghazaleh Freissmuth, Michael Wolzt, Michael Sci Rep Article Lead exposure can cause substantial organ damage. Enteral lead absorption may be reduced by concomitant intake of clinoptilolite tuff, a zeolite from natural sources. This study aimed to assess the effect of purified clinoptilolite tuff (G-PUR) on enteral lead uptake in adults using stable lead isotope (204)Pb as a tracer. In this randomized, placebo-controlled, double-blind, parallel-group study, 42 healthy participants were randomized to receive oral G-PUR 2.0 g, 2 * 2.0 g, or placebo, together with 2.5 µg of (204)Pb in water. The enrichment of (204)Pb caused by the tracer in blood and urine was measured by mass spectrometry. G-PUR was well tolerated. The mean maximum (204)Pb enrichment of 0.505% of total blood lead was significantly higher (p < 0.0001) in the placebo group compared to G-PUR 2.0 g (0.073%) or G-PUR 2 * 2.0 g (0.057%) group. Normalized (204)Pb AUC(0-192) was 86.5, 11.9, and 8.5% * h without and with G-PUR 2.0 g, and G-PUR 2 * 2.0 g, respectively (p < 0.0001 vs. placebo). This smaller (204)Pb exposure was paralleled by a reduced urinary excretion in subjects receiving G-PUR. Concomitant oral intake of purified clinoptilolite tuff reduced enteral uptake of (204)Pb in healthy humans by approximately 90%. The reduced bioavailability is demonstrable by a decrease of (204)Pb tracer enrichment in blood and urine. Trial registration: clinicaltrials.gov identifier: NCT04138693, registered 24/10/2019. Nature Publishing Group UK 2021-07-20 /pmc/articles/PMC8292361/ /pubmed/34285282 http://dx.doi.org/10.1038/s41598-021-94245-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Samekova, Karolina
Firbas, Christa
Irrgeher, Johanna
Opper, Christine
Prohaska, Thomas
Retzmann, Anika
Tschegg, Cornelius
Meisslitzer, Claudia
Tchaikovsky, Anastassiya
Gouya, Ghazaleh
Freissmuth, Michael
Wolzt, Michael
Concomitant oral intake of purified clinoptilolite tuff (G-PUR) reduces enteral lead uptake in healthy humans
title Concomitant oral intake of purified clinoptilolite tuff (G-PUR) reduces enteral lead uptake in healthy humans
title_full Concomitant oral intake of purified clinoptilolite tuff (G-PUR) reduces enteral lead uptake in healthy humans
title_fullStr Concomitant oral intake of purified clinoptilolite tuff (G-PUR) reduces enteral lead uptake in healthy humans
title_full_unstemmed Concomitant oral intake of purified clinoptilolite tuff (G-PUR) reduces enteral lead uptake in healthy humans
title_short Concomitant oral intake of purified clinoptilolite tuff (G-PUR) reduces enteral lead uptake in healthy humans
title_sort concomitant oral intake of purified clinoptilolite tuff (g-pur) reduces enteral lead uptake in healthy humans
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292361/
https://www.ncbi.nlm.nih.gov/pubmed/34285282
http://dx.doi.org/10.1038/s41598-021-94245-x
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